{"paper_id":"887629df-64d1-4e2b-9390-79b0e8a01cfc","body_text":"WS1-03\nAbstract:\nWe monitored (from 1976–2005) thousands of people affected by the fallout of TCDD over Seveso on July 10, 1976. Serum samples have been kept frozen and it has been possible after 1988 to measure the TCDD blood lipid content.\nThe results indicate that:\nChloracne was the only clinical alteration, which partly correlated to TCDD contamination levels with differing individual susceptibility; and\nMiscarriages, perinatal mortality, low birth weight, and congenital malformations did not significantly increase.\nPart of the exposed subjects were followed up from 1992 to 2005. The results showed that:\nNo pathologic laboratory results were related to TCDD levels;\nThe half-life of TCDD was longer in women (approximately 9 years) than in men (approximately 7.5 years) and much shorter in children;\nA doubled, nonsignificant risk for endometriosis in women was associated with serum TCDD levels of 100 ppt or higher;\nAmong premenarcheal women, serum TCDD level was associated with a lengthening of the menstrual cycle by 0.93 days;\nThe hazard ratio for breast cancer associated with serum TCDD levels was significantly increased to 2.1;\nA skewing of the sex ratio at birth with an excess of females (P < 0.001) from parents exposed to TCDD was observed and it was permanently related only to exposure of the father; and\nDevelopmental dental aberrations were registered as well associated with childhood exposure.","source_license":"CC0","license_restricted":false}