Perfil diferencial de transcritos em endométrio eutópico de mulheres inférteis com endometriose e controles durante a janela de implantação

Michele Gomes Da Broi, Carlos Valério Rocha‐Junior, Jéssica Rodrigues Plaça, Wilson A. Silva, Rui Alberto Ferriani, Paula Andrea Navarro
In: Reprodução & Climatério · 2017 · vol. 32(2) , pp. 97–103 · doi:10.1016/j.recli.2017.03.002 · W2626348629
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This study compared gene expression in the eutopic endometrium of infertile women with endometriosis, infertile controls, and fertile controls, finding differences in advanced endometriosis patients.

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Abstract

Alterações moleculares no endométrio eutópico de mulheres com endometriose podem estar envolvidas na infertilidade associada à doença. Este estudo objetivou comparar os genes diferencialmente expressos (DEG) no endométrio eutópico de mulheres inférteis com endometriose, controles inférteis (CI; fator masculino e/ou tubário) e controles férteis (CF) durante a janela de implantação, através de RNA‐Seq. Biópsias endometriais foram obtidas de 17 pacientes (seis inférteis com endometriose, seis CI e cinco CF) durante a janela de implantação. O RNA total foi extraído e o RNA‐Seq foi feito na plataforma Illumina HISEQ 2500, high output, paired end. A normalização dos dados e a expressão diferencial foram conduzidas no ambiente estatístico R através do pacote DESeq2. Os grupos CI e CF foram semelhantes. Nenhum DEG foi identificado quando comparados os grupos CF e endometriose (independentemente do estágio da doença). Cinco DEGs (SCUBE1, CCL20, LGALS9 C, TRIM 29 e WNT11) foram identificados no grupo endometriose avançada (EIII/IV) e um DEG (KANSL1‐AS1) no grupo endometriose inicial (EI/II), quando comparados com o CF. Dois DEGs (KANSL1‐AS1 e VGLL3) foram identificados com a comparação de EI/II e EIII/IV. Os dados sugerem que o endométrio eutópico de mulheres inférteis com endometriose, especialmente na doença avançada, seja molecularmente diferente do endométrio eutópico de mulheres férteis durante a janela de implantação. Molecular alterations in the eutopic endometrium of women with endometriosis may be involved in the endometriosis‐related infertility. This study aimed to compare the differentially expressed genes (DEG) in eutopic endometrium of infertile women with endometriosis, infertile controls (IC; male and/or tubal factor) and fertile controls (FC) through RNA‐Seq. Endometrial biopsies were obtained from 17 patiens (6 infertile women with endometriosis, 6 IC and 5 FC) during the implantation window. The RNA was extracted and the RNA‐Seq was performed at a HISEQ 2500 Illumina Platform, high output, paired end. Standardization and differential expression were conducted in the statistical R environment using DESeq2 package. The groups IC and FC were similar. No DEG has been identified comparing CF and endometriosis groups. Five DEGs (SCUBE1, CCL20, LGALS9 C, TRIM 29 e WNT11) were identified in the advanced endometriosis (EIII/IV) group, and 1 (KANSL1‐AS1) in the initial endometriosis (EI/II) group compared to FC. Two DEGs (KANSL1‐AS1 and VGLL3) were identified by comparing EI/II and EIII/IV groups. These data suggest that the eutopic endometrium of infertile women with endometriosis, especially those with advanced disease, may be molecularly different from those of fertile women during the implantation window.

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Condition tags

endometriosisinfertility

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (35)

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