A prospective trail comparing hysterectomy, hysterectomy plus vaginal radium, and uterine radium plus hysterectomy in stage I endometrial carcinoma

M S Piver, Piver MS, R Yazigi, Yazigi R, Blumenson L, L Blumenson, Tsukada Y, Y Tsukada
Obstetrics and gynecology · 1979 · doi:10.1097/00006250-197907000-00020 · PMID:450367
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-05 ⓘ

A prospective trial in stage I endometrial carcinoma found no statistically significant survival differences among hysterectomy alone, preoperative radium plus hysterectomy, or hysterectomy plus postoperative radium.

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This 1958 to 1967 prospective randomized trial evaluated survival outcomes in 189 women with stage I group I endometrial adenocarcinoma. The study compared three treatment arms: hysterectomy alone, preoperative uterine radium followed by hysterectomy, and postoperative vaginal radium combined with hysterectomy. After a minimum ten-year follow-up, actuarial survival rates at five and ten years were high and showed no statistically significant differences among the three groups. However, the researchers noted that tumor grade significantly influenced survival, with grade III lesions associated with poorer outcomes compared to lower grades. This paper is centrally about endometrial carcinoma, a distinct gynecologic malignancy, and does not address endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

From 1958 to 1967, a prospective randomized trial was conducted in 189 women with stage I, group I endometrial adenocarcinoma, comparing treatment by hysterectomy alone, preoperative uterine radium followed by hysterectomy, and hysterectomy and postoperative vaginal radium. All women have been followed for a minimum of 10 years. The actual survival rate at 5 years for all patients was 94.5% and at 10 years, 92.6%, with no statistical significance among the 3 treatment groups. Ther was also no statistical significance in survival rate in relation to size of uterine or myometrial invasion. There was a statistically significant difference in survival between grade I and grade III lesions (P less than 0.01) and between grade II and grade III lesions (P less than 0.05).
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A Prospective Trial Comparing Hysterectomy, Hysterectomy Plus Vaginal Radium, and Uterine Radium Plus Hysterectomy in Stage I Endometrial Carcinoma - STEVEN M. PIVER - ROBERTO YAZIGI - LESLIE BLUMENSON - YOSHIAKI TSUKADA From 1958 to 1967, a prospective randomized trial was conducted in 189 women with stage I, group I endometrial adenocarcinoma, comparing treatment by hysterectomy alone, preoperative uterine radium followed by hysterectomy, and hysterectomy and postoperative vaginal radium. All women have been followed for a minimum of 10 years. The actuarial survival rate at 5 years for all patients was 94.5% and at 10 years, 92.6%, with no statistical significance among the 3 treatment groups. There was also no statistical significance in survival rate in relation to size of uterine or myometrial invasion. There was a statistically significant difference in survival between grade I and grade III lesions (P< 0.01) and between grade II and grade III lesions (P< 0.05).

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Endometriosis Hysterectomy Radium Uterine Neoplasms Adenocarcinoma Adenocarcinoma Castration Endometriosis Endometriosis Female Follow-Up Studies Humans Neoplasm Staging Prospective Studies Radium Random Allocation Uterine Neoplasms Uterine Neoplasms Uterus

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europepmc
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pubmed
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