ROLE OF LHRH ANALOGUE IN CASES OF REFRACTORY MASTALGIA.

Rinku Kumari, Ankur Akela, Pradeep Jaiswal, Pawan Kr. Jha
In: INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH · 2022 · pp. 17–18 · doi:10.36106/ijsr/0406569 · W4313442390
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This study found that the GnRH analogue goserelin is a safe and effective treatment for refractory mastalgia, reducing pain scores in fifty patients over six months.

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This prospective cohort study evaluated the efficacy of complete estrogen blockade using centchroman and the LHRH analogue goserelin for treating refractory mastalgia. The research involved fifty patients with bilateral breast pain, measuring outcomes based on a reduction in visual analog scale scores to three or less within six weeks of initiating treatment. The authors concluded that this hormonal intervention is both safe and effective for alleviating symptoms in women suffering from chronic breast pain. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background: Mastalgia is the commonest cause of visit to the breast clinic. The present study was conducted to assess the efcacy of complete estrogen blockade (CEB) with centchroman and LHRH analog goserelin in the treatment of refractory mastalgia. Aim: To study the effect of LHRH analogue in refractory mastalgia and to increase pain free period in patients with refractory mastalgia. Methods: This is a prospective cohort study conducted in the Dept.Of Gen.Surgery IGIMS ,Patna over a period of six months.The reduction of pain score ( as measured by a visual analog scale (VAS) recorded on a breast pain chart ) to 3 or less at 6 weeks of initiation of treatment was taken as primary objective. Results: Fifty patients were enrolled in the study. The mean age of the patients was 28 years (15–45 years). The median duration of symptoms was 6 months (4–8). All of them had bilateral mastalgia. The mean pain score at start of study was 7. Conclusion: Complete estrogen blockade by means of GNRH analogue is safe and effective for treatment of refractory mastalgia.
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Keywords

Mastalgia, Complete estrogen blockade. GNRH analogue.Abstract

Background

Mastalgia is the commonest cause of visit to the breast clinic. The present study was conducted to assess the efficacy of complete estrogen blockade (CEB) with centchroman and LHRH analog goserelin in the treatment of refractory mastalgia. Aim: To study the effect of LHRH analogue in refractory mastalgia and to increase pain free period in patients with refractory mastalgia. Methods: This is a prospective cohort study conducted in the Dept.Of Gen.Surgery IGIMS ,Patna over a period of six months.The reduction of pain score ( as measured by a visual analog scale (VAS) recorded on a breast pain chart ) to 3 or less at 6 weeks of initiation of treatment was taken as primary objective. Results: Fifty patients were enrolled in the study. The mean age of the patients was 28 years (15–45 years). The median duration of symptoms was 6 months (4–8). All of them had bilateral mastalgia. The mean pain score at start of study was 7. Conclusion: Complete estrogen blockade by means of GNRH analogue is safe and effective for treatment of refractory mastalgia. Downloads Published How to Cite Issue Section License Copyright (c) 2022 Rinku Kumari, Ankur Akela, Pradeep Jaiswal, Pawan Kr. Jha This work is licensed under a Creative Commons Attribution 4.0 International License.

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VAS-pain

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