Effect of danazol on plasma lipid and lipoprotein levels in normal women

A A Luciano, Anthony A. Luciano, Luciano AA, Wallace RB, R B Wallace, Robert B. Wallace, B M Sherman, Sherman BM, Barry M. Sherman
Atherosclerosis · 1982 · vol. 43(1) , pp. 133–137 · doi:10.1016/0021-9150(82)90105-8 · PMID:7092979 · W2043662798
Non-randomised trial OA: closed CC0 ⤵ 4 in-corpus citations
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This study investigated the effects of danazol administration on plasma lipid and lipoprotein concentrations in healthy women.

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Abstract

Prior studies of lipid and lipoprotein levels alterations associated with the administration of danazol, a testosterone derivative, in patients treated for endometriosis have been conflicting. We administered danazol to 7 normal menstruating women and measured plasma lipid and lipoprotein cholesterol levels prior to and 2 months after treatment. Small, non-significant decreases in total plasma cholesterol and triglyceride levels were seen, largely due to a dramatic decline in one woman with type IV hyperlipoproteinemia. No significant change in low density or very low density lipoprotein cholesterol levels was seen. However, a marked (40%) reduction of high density lipoprotein cholesterol level in the mean was found. These findings have implications for the atherogenic potential of danazol, the treatment of hyperlipidemia, and the relationship between gonadal hormones and lipoprotein levels.

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MeSH descriptors

Danazol Lipids Lipoproteins Pregnadienes Adult Adult Cholesterol Cholesterol Cholesterol Danazol Danazol Female Female Humans Humans Lipids Lipids Lipoproteins Lipoproteins Menstruation

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

Cited by (4)

References (12)

Cited by (4)

SciLite annotations

chemicals 18
danazol lipid lipoprotein lipid lipoprotein danazol testosterone danazol lipid lipoprotein cholesterol cholesterol triglyceride cholesterol lipoprotein cholesterol danazol lipoprotein
organisms 2
noordeloos 2009062 noordeloos 2009062

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License: CC0 · commercial use OK