c-myc, c-erb-B2, nm23 and p53 expression in human endometriosis

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This study found c-myc and nm23 expression in 53.3% and 43.7% of endometriosis samples, respectively, while c-erb-B2 and p53 were undetectable.

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Abstract

We studied the expression of oncogenes and tumor-suppressor genes in human endometriosis in a retrospective pilot study. Sixteen patients with histologically verified pelvic endometriosis at the university-based tertiary care referral center were studied. Immunohistochemical determination of c-myc, c-erb-B2, nm23 and p53 expression in archival, paraffin-embedded pathological samples were used from patients operated upon for pelvic endometriosis. c-myc was expressed in 8/15 cases (53.3%). nm23 was expressed in 7/16 cases (43.7%). c-erb-B2 and p53 reactivity was undetectable in the samples studied. The c-myc oncogene and nm23 are overexpressed in many cases of endometriosis, and may play a still undefined role in its pathogenesis. Immuno-histochemistry is a useful tool for the study of oncogenic activation in this disease.
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Print ISSN: 1021-335X Online ISSN: 1791-2431 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 49-101|Published online on: January 1, 1998https://doi.org/10.3892/or.5.1.49 - Expand metrics + We studied the expression of oncogenes and tumor-suppressor genes in human endometriosis in a retrospective pilot study. Sixteen patients with histologically verified pelvic endometriosis at the university-based tertiary care referral center were studied. Immunohistochemical determination of c-myc, c-erb-B2, nm23 and p53 expression in archival, paraffin-embedded pathological samples were used from patients operated upon for pelvic endometriosis. c-myc was expressed in 8/15 cases (53.3%). nm23 was expressed in 7/16 cases (43.7%). c-erb-B2 and p53 reactivity was undetectable in the samples studied. The c-myc oncogene and nm23 are overexpressed in many cases of endometriosis, and may play a still undefined role in its pathogenesis. Immuno-histochemistry is a useful tool for the study of oncogenic activation in this disease. Copy and paste a formatted citation Spandidos Publications style Schneider J, Jimenez E, Rodriguez F and del Tanago J: c-myc, c-erb-B2, nm23 and p53 expression in human endometriosis.. Oncol Rep 5: 49-101, 1998. APA Schneider, J., Jimenez, E., Rodriguez, F., & del Tanago, J. (1998). c-myc, c-erb-B2, nm23 and p53 expression in human endometriosis.. Oncology Reports, 5, 49-101. https://doi.org/10.3892/or.5.1.49 MLA Schneider, J., Jimenez, E., Rodriguez, F., del Tanago, J."c-myc, c-erb-B2, nm23 and p53 expression in human endometriosis.". Oncology Reports 5.1 (1998): 49-101. Chicago Schneider, J., Jimenez, E., Rodriguez, F., del Tanago, J."c-myc, c-erb-B2, nm23 and p53 expression in human endometriosis.". Oncology Reports 5, no. 1 (1998): 49-101. https://doi.org/10.3892/or.5.1.49

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Erb-b2 Receptor Tyrosine Kinases Genes, erbB-2 Genes, myc Genes, Tumor Suppressor Monomeric GTP-Binding Proteins Nucleoside-Diphosphate Kinase Proto-Oncogene Proteins c-myc Transcription Factors Uterine Diseases Biopsy Endometriosis Endometriosis Endometriosis Erb-b2 Receptor Tyrosine Kinases Erb-b2 Receptor Tyrosine Kinases Female Genes, p53 Humans NM23 Nucleoside Diphosphate Kinases

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pubmed
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