ENDOMETRİOZİSE BAĞLI AĞRI TEDAVİSİNDE LEVONORGESTREL SALGILAYAN RAHİM İÇİ ARAÇ SİSTEMİ (LNG-RİA) VE NAPROKSEN SODYUM ETKİNLİĞİ KARŞILAŞTIRILMASI

Şengül Talar Arslan, Bünyamin Börekçi, Emsal Pınar Topdağı Yılmaz
In: Mustafa Kemal Üniversitesi Tıp Dergisi · 2016 · pp. 37 · doi:10.17944/mkutfd.287836 · W2580550995
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study compared the efficacy of levonorgestrel-releasing intrauterine devices (LNG-IUD) and naproxen sodium for endometriosis pain, finding LNG-IUD to be more effective.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This study compared the efficacy of a levonorgestrel-releasing intrauterine system (LNG-IUD) versus naproxen sodium for endometriosis-related pain in 60 patients with surgically/pathologically confirmed endometriosis, randomized into three groups (control, LNG-IUD, naproxen) with monthly follow-up over six months. Pain outcomes were measured using the McGill pain questionnaire and a visual analogue scale, tracked monthly, and statistical testing assessed changes over time. The LNG-IUD group showed a statistically significant decrease in mean VAS scores from month 1 to month 6, while the naproxen sodium group had reductions in pelvic pain and dysmenorrhea but no difference in pain severity reduction between months. This paper is centrally about endometriosis — it directly evaluates LNG-IUD versus naproxen sodium for treatment of endometriosis-related pain.

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Abstract

Aim: Although there are many symptoms of endometriosis, the most frequent symptom is pain. The cause of pain is unknown. In this study, it is aimed to compare efficiency of LNG-IUD (levonorgestrel releasing intrauterine vehicle system) and the non-steroidal anti-inflammatory agent, naproxen sodium which are two current approaches in the management of endometriosis-related pain. Material and Methods: After approval of the Ethics Committee, 60 patients, who were operated with the pathology of endometriosis, were included in the study.It is divided into three groups and each group cotained 20 patients.They are named as the control group, the LNG-IUD group, and the naproxen sodium group. McGill pain questionnaire and pain questionnaire form were given to patients monthly. Patients were asked to fill out the forms using a visual analogue scale. Patients were followed-up monthly. Results: As a result of the statistical tests applied, there was a significant decrease in the mean VAS score in the LNG- IUD patient group from 1st to the 6th months of treatment. Reduction of pelvic pain and dysmenorrhea was detected in the naproxen sodium group, but it did not differ the decrease in pain severity between months 0 0 1 223 1277 MKU 10 2 1498 14.0 Normal 0 false false false TR JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0cm; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-ansi-language:TR;} Conclusion: A number of medical drugs are used in the management of endometriosis-related pain. It can be concluded that LNG-IUD was a more effective due to modality in the management of endometriosis-related pain, and has both low side effct and no need to be used continously.
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Material and methods

After approval of the Ethics Committee, 60 patients, who were operated with the pathology of endometriosis, were included in the study.It is divided into three groups and each group cotained 20 patients.They are named as the control group, the LNG-IUD group, and the naproxen sodium group. McGill pain questionnaire and pain questionnaire form were given to patients monthly. Patients were asked to fill out the forms using a visual analogue scale. Patients were followed-up monthly.

Results

As a result of the statistical tests applied, there was a significant decrease in the mean VAS score in the LNG- IUD patient group from 1st to the 6th months of treatment. Reduction of pelvic pain and dysmenorrhea was detected in the naproxen sodium group, but it did not differ the decrease in pain severity between months

Conclusion

A number of medical drugs are used in the management of endometriosis-related pain. It can be concluded that LNG-IUD was a more effective due to modality in the management of endometriosis-related pain, and has both low side effct and no need to be used continously. Anahtar Kelimeler Kaynakça - Mahmood TA, Templeton A, Thomson L, Fraser Cl. Menstrual symtoms in women with pelvic endometriosis. Br J Obstet Gynecol 1991; 98: 555-63. - Barry AR, Daniel CM. Endometriosis and chronic pelvic pain. Obstet Gynecol Clin NA 1993; 20: 709-17. - Fedele L, Parazzini F, Bianchi S, Arcaini L, Candiani GB. Stage and localization of pelvic endometriosis and pain. Fertil Steril 1990; 53: 155-58. - Fedele L, Bianchi S, Bocciolona L, Di Nola G, Parazzini F. Pain symptoms associated with endometriosis. Obstet Gynecol 1992; 75: 767-69. - Mishell DR Jr. Intrauterine devices. Curr Ther Endocrinol Metab 1997; 6: 285-92. - Eray S , Bakır SA, Hazar Aİ , Güneş J , İzmir M , Ortaylı N , et al. Farma List (1. baskı). 2001, Farmatıp Yayıncılık: Ankara. 388-405. - Melzack R. The McGill Pain Questionnaire: Major properties and scoring methods. Pain. 1975; 1: 277-99. - Kuğuoğlu S, Aslan FE, Olgun N. McGill Melzack ağrı soru formunun (MASF) Türkçe'ye uyarlanması. Ağrı. 2003; 47-51. Ayrıntılar Birincil Dil İngilizce Konular - Bölüm Araştırma Makalesi Yayımlanma Tarihi 31 Aralık 2016 Gönderilme Tarihi 24 Ocak 2017 Kabul Tarihi 6 Kasım 2016 Yayımlandığı Sayı Yıl 2016 Cilt: 7 Sayı: 28

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VAS-pain

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endometriosisdysmenorrhea

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