[Is cryosurgery as alternative treatment procedure for recurrent hyperplasia of the endometrium in perimenopause to be considered?].

Complex investigations were performed for the evaluation of the local biological effect of the total cryodestruction of endometrium in 7 perimenopausal women with relapsing hyperplasia of the endometrium before and after (in 3-4.5 months) surgery. The following methods were used: radiometry of uterus, cytomorphologic and cytomorphometric investigations, RIA of E2 in peripheral blood plasma, in cytosol and in a nuclear fraction, and an assay of the state of E2-receptor endometrial system. The results of the investigations showed the importance of these methods as the objective criteria for the treatment efficiency. It was established that the cryosurgery is an alternative method for the treatment of this pathology in perimenopausal women.