Zhibai dihuang pill (ZBDH) exhibits therapeutic effects on idiopathic central sexual precocity in rats by modulating the gut microflora

Canhong Yi; Hui Zou; Xiaojuan Lin; Shanshan Liu; Juan Wang; Yuquan Tian; Xujing Deng; Jianhong Luo; Chan Li; Yin Long

doi:10.1016/j.heliyon.2024.e29723

Zhibai dihuang pill (ZBDH) exhibits therapeutic effects on idiopathic central sexual precocity in rats by modulating the gut microflora

Canhong Yi, Hui Zou, Xiaojuan Lin, Shanshan Liu, Juan Wang, Yuquan Tian, Xujing Deng, Jianhong Luo, Chan Li, Yin Long

In: Heliyon · 2024 · vol. 10(9) , pp. e29723 · doi:10.1016/j.heliyon.2024.e29723 · PMID:38707434 · W4394844059

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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

Zhibai dihuang pill (ZBDH) effectively treated idiopathic central sexual precocity in rats, with its therapeutic impact potentially linked to alterations in gut microbiota composition.

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Abstract

abundance. ZBDH and GnRHa were effective in treating Danazol-induced ICPP model rats. The therapeutic effects of ZBDH and GnRHa could be related to the changes in GM in rats.

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Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds via openalex
The Traditional Chinese Medicine Fuyou Formula Alleviates Precocious Puberty by Inhibiting GPR54/GnRH in the Hypothalamus via openalex
doi:10.1111/j.2047-6310.2013.00176.x via openalex
doi:10.3389/fendo.2021.762691 via openalex
doi:10.1038/sj.embor.7400731 via openalex
doi:10.1159/000504446 via openalex
doi:10.1097/md.0000000000036395 via openalex
doi:10.7499/j.issn.1008-8830.2108078 via openalex
doi:10.1155/2020/1978043 via openalex
doi:10.3389/fphar.2020.533841 via openalex
doi:10.3389/fmicb.2022.930747 via openalex
doi:10.1016/s2213-8587(15)00380-0 via openalex
W192467118 via openalex
doi:10.1155/2019/3949824 via openalex
doi:10.1080/19490976.2018.1465157 via openalex
doi:10.1016/s0254-6272(14)60033-9 via openalex
doi:10.1016/j.jep.2012.05.031 via openalex
doi:10.1210/endocr/bqz041 via openalex
doi:10.1007/s40272-015-0130-8 via openalex
doi:10.3389/fcimb.2021.618265 via openalex
doi:10.1016/j.jep.2017.05.006 via openalex
W3024817556 via openalex
doi:10.1016/j.yhbeh.2013.01.014 via openalex
doi:10.1080/13880209.2023.2199786 via openalex
doi:10.1002/ctm2.299 via openalex
W6751342965 via openalex
W6777136666 via openalex
W6789788882 via openalex
W6803903106 via openalex
W6808925677 via openalex
W6859008195 via openalex
doi:10.1186/s40168-022-01255-6 via openalex
doi:10.1371/journal.pone.0201906 via openalex
doi:10.1016/j.ctim.2014.01.002 via openalex
doi:10.3389/fcimb.2022.834485 via openalex
doi:10.3390/molecules22010007 via openalex
doi:10.1142/s0192415x21500130 via openalex
doi:10.1002/jssc.201300794 via openalex
doi:10.1038/s41419-019-1985-3 via openalex
doi:10.1016/j.phymed.2021.153654 via openalex
doi:10.1530/joe-13-0131 via openalex
doi:10.3389/fendo.2019.00941 via openalex
doi:10.1016/j.maturitas.2007.06.005 via openalex
doi:10.1016/j.heliyon.2023.e20889 via openalex

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[1] The Traditional Chinese Medicine Fuyou Formula Alleviates Precocious Puberty by Inhibiting GPR54/GnRH in the Hypothalamus 2021

[2] Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds 2021