AARS1 promotes endometriosis progression by promoting the lactylation of Snail1†

Lan Liu, Liu L, Shiyu Du, Du S, Liu J, Jiayu Liu, Wang M, Mengze Wang, Xiaofang Ge, Ge X, Xiangyu Ge, Chenjing Yue, Yue C, Congbo Yue, Chao Lü, Zhenhai Yu
Biology of reproduction · 2025 · vol. 113(5) , pp. 1209–1218 · doi:10.1093/biolre/ioaf188 · PMID:40815826 · W4413257131
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

Alanyl-tRNA synthetase 1 (AARS1) promotes endometriosis progression by enhancing the lactylation and stability of Snail1, thereby boosting the proliferation and invasiveness of endometriotic stromal cells.

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Abstract

The widely accepted theory of endometriosis posits that endometriosis stems from the translocation of endometrial tissue through the fallopian tubes into the abdominal cavity. However, the exact pathogenesis and critical molecules of endometriosis remain unclear. Here, we find that alanyl-tRNA synthetase 1 (AARS1) is abundantly expressed in endometrial tissues and promotes the proliferation, migratory capability, and invasive potential in endometriotic stromal cells (EESC) and 11Z cells. Moreover, AARS1 enhances epithelial-to-mesenchymal transition in EESC and 11Z cells. In addition, AARS1 could lactylate Snail1 to maintain its protein stability. In summary, this work identifies a crucial role of AARS1 in advancing endometriosis, which may provide new insights into its pathogenesis and future disease management.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (23)

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