Ibuprofen therapy for dysmenorrhea
RCT
OA: closed
CC0
⤵ 12 in-corpus citations
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This double-blind crossover study found ibuprofen to be statistically superior to aspirin and placebo in relieving dysmenorrhea pain, confirmed by patient drug preference.
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Abstract
Thirty-three dysmenorrheic patients were given ibuprofen, aspirin and a placebo in a double-blind crossover study, with each drug taken during one of three successive menstrual cycles in random sequence. Paired drug comparisons demonstrated the statistical superiority of ibuprofen, as compared with the other two, for the relief of pain. Data evaluated according to patient drug preference showed similar results. The role of nonsteroidal antiinflammatory drugs in therapy for dysmenorrhea is discussed.
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Cited by (11)
- Theories on the Pathogenesis of Endometriosis 2011
- Emerging drugs for endometriosis 2008
- Evolution of medical treatment for endometriosis: back to the roots? 2007
- Diagnosis and treatment of endometriosis 2003
- Endometriosis: an overview of the disease and its treatment 2000
- Prostaglandin synthetase inhibitors in the treatment of primary dysmenorrhea. Outcome trials reviewed 1984
- Ibuprofen and dysmenorrhea 1984
- Prostaglandins and nonsteroidal antiinflammatory drugs in dysmenorrhea 1983
- Naproxen sodium, aspirin, and placebo in primary dysmenorrhea. Reduction of pain and blood levels of prostaglandin F2-alpha metabolite 1981
- Dysmenorrhoea and prostaglandins: pharmacological and therapeutic considerations 1981
- Primary dysmenorrhea treatment with prostaglandin inhibitors: a review 1981
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:34:34.650872+00:00
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