Hemothorax after Lupron therapy of a patient with pleural endometriosis--a case report and literature review

M. T. Margolis, Margolis MT, Larynda D. Thoen, Thoen LD, L D Thoen, Mercer LJ, L J Mercer, Louis G. Keith, L G Keith, Keith LG
International journal of fertility and menopausal studies · 1996 · vol. 41(1) , pp. 53–5 · PMID:8673157 · W14262628
Case report OA: closed CC0 ⤵ 5 in-corpus citations
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This case report describes a patient with pleural endometriosis who developed a hemopneumothorax after initiating Lupron therapy, highlighting a previously undescribed exacerbation of pulmonary symptoms.

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Abstract

BACKGROUND: Pulmonary endometrial implants, although uncommon, have been well described in the literature. Symptoms occur with menses and may include recurrent pleuritic chest pain, pneumothorax, hemoptysis, or hemothorax. Exacerbation of pulmonary symptoms by Lupron therapy has not been previously described. CASE REPORT: A 38-year-old African-American female with known endometriosis but no history of pulmonary disease was evaluated for a 2-year history of severe dysmenorrhea. A trial of hormonal suppression was unsuccessful, and she was offered Lupron therapy. Three weeks after its initiation, and shortly after the onset of menses, she came to the emergency room with pleuritic chest pain and shortness of breath and was found to have a right-sided hemopneumothorax. Thoracentesis treatment was successful in eliminating this symptom. CONCLUSION: Although pulmonary endometriosis is rare, physicians should be aware that Lupron therapy can exacerbate pulmonary symptoms during the initial phase of therapy.

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Condition tags

endometriosisdysmenorrhea

MeSH descriptors

Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Endometriosis Hemothorax Leuprolide Leuprolide Pleural Diseases Adult Adult Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Endometriosis Endometriosis Female Female Hemothorax Hemothorax Humans Humans Leuprolide

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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