Synchronous primary endometrial and ovarian cancers: how to diagnose, differentiate and treat in the light of recent available literature data
article
OA: diamond
CC0
AI-generated summary
This paper reviews literature on synchronous endometrial and ovarian cancers, proposing updated diagnostic criteria beyond older Scully guidelines and discussing treatment management, particularly regarding fertility preservation.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
SEO – synchronous endometrial ovarian cancer is a well-known phenomenon, which has for years been managed as two primary independent cancers. The results of recent molecular studies, especially next-generation sequencing, suggest that the condition should be regarded as a continuum, with its origin probably lying in the endometrium or endometrial foci. It has been found that 0.7% to 1.0% of endometriosis patients may develop malignant lesions. Although SEO is being increasingly studied, diagnostics and treatment still leave many questions. The most important thing is to improve the diagnosis with rapid and simple detection. A few molecular methods are already known, but genetic diagnostic, still remains unclear. Old criteria implemented by Scully in 1998 should be nowadays complemented by immunohistochemical staining of estrogen and progestin receptors, bcl2 antibodies and molecular analyses of genes: B-catenin, PTEN, KRAS, TP53, PIK3CA and microsatellite instability. Will genetic diagnostics preserve fertility in young patients with SEO? This paper reviews relevant literature to determine a strategy for distinguishing between SEO and metastatic cancers, and presents management options for patients with SEO.
My notes (saved in your browser only)
Condition tags
Citation neighborhood (sparse)
Too few in-corpus citations on either side for a chart; here are the lists.
Cites (4)
- Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters 2004
- The origin of endometriosis-associated ovarian cancer from uterine neoplastic lesions 2017
- Clear cell ovarian cancer and endometriosis: is there a relationship? 2016
- Synchronous endometrial and ovarian carcinomas: predictors of risk and associations with survival and tumor expression profiles 2017
References (39)
- Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters via openalex
- Clear cell ovarian cancer and endometriosis: is there a relationship? via openalex
- Synchronous endometrial and ovarian carcinomas: predictors of risk and associations with survival and tumor expression profiles via openalex
- The origin of endometriosis-associated ovarian cancer from uterine neoplastic lesions via openalex
- W1995048267 via openalex
- W2040937491 via openalex
- W2041440766 via openalex
- W2043177767 via openalex
- W2052714294 via openalex
- W2054791534 via openalex
- W2061265681 via openalex
- W2084862658 via openalex
- W2086847526 via openalex
- W2110702895 via openalex
- W2138188033 via openalex
- W2142188072 via openalex
- W2153540232 via openalex
- W2162645859 via openalex
- W2191157318 via openalex
- W2270264837 via openalex
- W2561322813 via openalex
- W2768955837 via openalex
- W2778372347 via openalex
- W2789652899 via openalex
- W2792348180 via openalex
- W2809161129 via openalex
- W2900333014 via openalex
- W2903931775 via openalex
- W2905089141 via openalex
- W2908365730 via openalex
- W2909860909 via openalex
- W2923423787 via openalex
- W2972464382 via openalex
- W3189615500 via openalex
- W1664389184 via openalex
- W4241264858 via openalex
- W1872026285 via openalex
- W1922206815 via openalex
- W1994156828 via openalex
Source provenance
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0
· commercial use OK