Tibolone facilitates lordosis behavior through estrogen, progestin, and GnRH-1 receptors in estrogen-primed rats
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Tibolone administration enhanced lordosis behavior in estrogen-primed female rats by acting through estrogen, progestin, and GnRH-1 receptors.
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Abstract
A dose-response study was made of the broad-spectrum gonadal steroid agonist tibolone (TBL) on lordosis behavior in estradiol benzoate (EB: 5 µg) primed rats. Doses of TBL (0, 1, 4, and 16 μg) were infused to the right lateral ventricle 2 h before testing. The highest dose increased lordosis quotients significantly at 240 min and 360 min following infusion. However, the intensity of lordosis was weak. In experiment 2, the TBL dose of 16 µg was selected to determine whether tamoxifen (TMX), RU486, or antide could modify the lordosis response to TBL. Infusions of the three compounds, before TBL, significantly attenuated the TBL-induced facilitation of lordosis. The results suggest that TBL stimulates lordosis by activating estrogen, progesterone, and may do so by downstream stimulation of GnRH release. The physiological role TBL plays in controlling lordosis behavior remains to be determined.
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Cites (4)
- The effect of add-back treatment with tibolone (Livial) on patients treated with the gonadotropin-releasing hormone agonist triptorelin (Decapeptyl) 1996
- Prolonged use of gonadotropin-releasing hormone agonist and tibolone as add-back therapy for the treatment of endometrial hyperplasia 2003
- Pharmacological evidence that LH-RH action on lordosis behavior is mediated through a rise in cAMP 1982
- Estrogen receptor α and β are involved in the activation of lordosis behavior in estradiol-primed rats 2016
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SciLite annotations
chemicals 10
tibolone
estrogen
progestin
estrogen
steroid
tibolone
estriol acetate benzoate
tamoxifen
estrogen
progesterone
organisms 2
rattus sp.
rattus sp.
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- scilite
- last seen: 2026-05-18T04:26:01.642840+00:00
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