The challenges of chronic pain and fatigue

Jessica A Eccles, Jessica Eccles, Davies KA, Kevin A Davies
Clinical medicine (London, England) · 2021 · vol. 21(1) , pp. 19–27 · doi:10.7861/clinmed.2020-1009 · PMID:33479064 · PMC7850224
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This review examines the clinical burden and overlapping nature of chronic pain and fatigue, exploring pathological associations like joint hypermobility and small fiber neuropathy to inform multidisciplinary management strategies.

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Abstract

In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the 'clinical problem'. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory and interoceptive processes, which may inform treatment targets. We suggest a multidisciplinary management approach.

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MeSH descriptors

Chronic Pain Chronic Pain Joint Instability Fatigue Fatigue Humans

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europepmc
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pubmed
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License: CC-BY-NC-ND-4.0