Introduction to Preclinical Evidence from Animal Models of Endometriosis

Kathy L Sharpe-Timms, Julie A W Stilley
Advances in anatomy, embryology, and cell biology · 2020 · doi:10.1007/978-3-030-51856-1_1 · PMID:33278004
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Animal models are crucial for understanding endometriosis's causes and mechanisms, aiding the development of diagnostics, treatments, and prevention strategies for affected women.

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This chapter provides an introduction to preclinical evidence from animal models of endometriosis, describing the rationale for using animal studies given the impracticality and ethical constraints of randomized, double-blinded controlled trials in women. It outlines biological and epidemiological background of endometriosis, major symptoms, and discusses how endocrine-disrupting chemicals and an example epigenetic factor have been investigated as contributors to the disorder. The chapter’s stated caveat is that it is an introductory overview rather than a detailed presentation of specific experimental findings, positioning mechanistic insight as a primary goal. This paper is centrally about endometriosis—introducing preclinical evidence and key biological factors investigated using animal models.

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Abstract

Endometriosis, the presence and growth of uterine endometrial glandular epithelial and stroma cells outside the uterine cavity, causes pain and infertility in women and girls of reproductive age. As randomized, double-blinded, controlled studies of endometriosis in women are impractical and at times ethically prohibitive, animal models for endometriosis arose as an important adjunct to gain mechanistic insights into the etiology and pathophysiological mechanisms of this perplexing disorder. A more thorough understanding of endometriosis in women may help develop novel noninvasive diagnostics, classification systems, therapeutic regimes, and even preventative methods for the management of endometriosis. This chapter is intended to introduce a brief historical background, biological and epidemiological aspects, the major symptoms, the effects of endocrine-disrupting chemicals, and an example of an epigenetic factor of endometriosis in women.
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Abstract Endometriosis, the presence and growth of uterine endometrial glandular epithelial and stroma cells outside the uterine cavity, causes pain and infertility in women and girls of reproductive age. As randomized, double-blinded, controlled studies of endometriosis in women are impractical and at times ethically prohibitive, animal models for endometriosis arose as an important adjunct to gain mechanistic insights into the etiology and pathophysiological mechanisms of this perplexing disorder. A more thorough understanding of endometriosis in women may help develop novel noninvasive diagnostics, classification systems, therapeutic regimes, and even preventative methods for the management of endometriosis. This chapter is intended to introduce a brief historical background, biological and epidemiological aspects, the major symptoms, the effects of endocrine-disrupting chemicals, and an example of an epigenetic factor of endometriosis in women. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2020 Springer Nature Switzerland AG About this chapter Cite this chapter Sharpe-Timms, K.L., Stilley, J.A.W. (2020). Introduction to Preclinical Evidence from Animal Models of Endometriosis. In: Sharpe-Timms, K.L. (eds) Animal Models for Endometriosis. Advances in Anatomy, Embryology and Cell Biology, vol 232. Springer, Cham. https://doi.org/10.1007/978-3-030-51856-1_1 Download citation DOI: https://doi.org/10.1007/978-3-030-51856-1_1 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-51855-4 Online ISBN: 978-3-030-51856-1 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometrium Infertility, Female Animals Disease Models, Animal Endometriosis Endometriosis Endometrium Female Humans Infertility, Female Infertility, Female

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