{"paper_id":"7ec5fed5-b227-44ee-bad5-28f22a4f3299","body_text":"Abstract\nEndometriosis, the presence and growth of uterine endometrial glandular epithelial and stroma cells outside the uterine cavity, causes pain and infertility in women and girls of reproductive age. As randomized, double-blinded, controlled studies of endometriosis in women are impractical and at times ethically prohibitive, animal models for endometriosis arose as an important adjunct to gain mechanistic insights into the etiology and pathophysiological mechanisms of this perplexing disorder. A more thorough understanding of endometriosis in women may help develop novel noninvasive diagnostics, classification systems, therapeutic regimes, and even preventative methods for the management of endometriosis. This chapter is intended to introduce a brief historical background, biological and epidemiological aspects, the major symptoms, the effects of endocrine-disrupting chemicals, and an example of an epigenetic factor of endometriosis in women.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2020 Springer Nature Switzerland AG\nAbout this chapter\nCite this chapter\nSharpe-Timms, K.L., Stilley, J.A.W. (2020). Introduction to Preclinical Evidence from Animal Models of Endometriosis. In: Sharpe-Timms, K.L. (eds) Animal Models for Endometriosis. Advances in Anatomy, Embryology and Cell Biology, vol 232. Springer, Cham. https://doi.org/10.1007/978-3-030-51856-1_1\nDownload citation\nDOI: https://doi.org/10.1007/978-3-030-51856-1_1\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-030-51855-4\nOnline ISBN: 978-3-030-51856-1\neBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)","source_license":"public-domain-us","license_restricted":false}