Expressions of Livin and Smac and their correlation in endometriosis

Ping Zhu, Shuna Shen
In: Discussion of Clinical Cases · 2018 · vol. 5(1) , pp. 9 · doi:10.14725/dcc.v5n1p9 · W4241586619
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This study found that endometriosis tissues exhibit significantly higher Livin and lower Smac expression than normal controls, with these proteins negatively correlated in both eutopic and ectopic lesions regardless of clinical stage.

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This study investigated the expression levels of Livin and Smac proteins in endometrial tissues from 60 patients with endometriosis compared to 30 controls with normal endometrium. Immunohistochemical analysis revealed that Livin expression was significantly elevated while Smac expression was significantly reduced in both eutopic and ectopic endometrial tissues of the disease group. The researchers found a strong negative correlation between Livin and Smac levels, but neither protein's expression varied significantly with clinical staging or menstrual cycle phase. These findings suggest that altered apoptosis regulation via these proteins contributes to the pathogenesis of the condition. This paper is centrally about endometriosis — specifically examining molecular mechanisms involving apoptosis inhibition in ectopic endometrial lesions.

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Abstract

Objective: To explore the expression of Livin (a new member of inhibitors of apoptosis proteins) and second mitochondriaderived activator of caspases (Smac) in endometriosis (EMs), and the relationship of Livin and Smac with menstrual cycle and clinical staging of EMs, as well as correlation analysis. Methods: 60 cases of patients, who were given laparoscopic surgery or laparotomy operation due to EMs (confirmed by postoperative pathological examinations) in Department of Obstetrics and Gynecology of the Third Affiliated Hospital of Inner Mongolia Medical College from October 2010 to April 2012, were selected and included into the study group. The study group was subdivided into the eutopic group and the ectopic group, each of which contained 30 cases (16 cases for the proliferative phase, 14 cases for the secretory phase). 30 samples of normal endometrial tissues were chosen as the control group. Immunohistochemical method (SP) was used to determine the expression of Livin and Smac proteins in each group, with statistical analysis conducted to the results. Results: The expression of Livin in eutopic and ectopic endometrial tissues in EMs was significantly higher than that in normal endometrial tissues in the control group, and the difference was statistically significant (χ 2 = 12.510, p < .05); The expression of Smac in eutopic and ectopic endometrial tissues in EMs was significantly lower than that in normal endometrial tissues in the control group, and the difference was statistically significant (χ 2 = 19.530, p .05); In the eutopic and the ectopic endometrial tissues in EMs, the expression of Livin was negatively correlated to the expression of Smac (r s = -0.933 and r s = -0.867 respectively, all p < .05). Conclusions: The high expression of Livin and the low expression of Smac enhance the abilities of hyperplasia and antiapoptosis of ectopic endometrial cells, which leads to the occurrence and development of EMs.
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Abstract

Objective: To explore the expression of Livin (a new member of inhibitors of apoptosis proteins) and second mitochondriaderived activator of caspases (Smac) in endometriosis (EMs), and the relationship of Livin and Smac with menstrual cycle and clinical staging of EMs, as well as correlation analysis.

Methods

60 cases of patients, who were given laparoscopic surgery or laparotomy operation due to EMs (confirmed by postoperative pathological examinations) in Department of Obstetrics and Gynecology of the Third Affiliated Hospital of Inner Mongolia Medical College from October 2010 to April 2012, were selected and included into the study group. The study group was subdivided into the eutopic group and the ectopic group, each of which contained 30 cases (16 cases for the proliferative phase, 14 cases for the secretory phase). 30 samples of normal endometrial tissues were chosen as the control group. Immunohistochemical method (SP) was used to determine the expression of Livin and Smac proteins in each group, with statistical analysis conducted to the results.

Results

The expression of Livin in eutopic and ectopic endometrial tissues in EMs was significantly higher than that in normal endometrial tissues in the control group, and the difference was statistically significant (χ2 = 12.510, p < .05); The expression of Smac in eutopic and ectopic endometrial tissues in EMs was significantly lower than that in normal endometrial tissues in the control group, and the difference was statistically significant (χ2 = 19.530, p .05); In the eutopic and the ectopic endometrial tissues in EMs, the expression of Livin was negatively correlated to the expression of Smac (rs = -0.933 and rs = -0.867 respectively, all p < .05).

Conclusions

The high expression of Livin and the low expression of Smac enhance the abilities of hyperplasia and antiapoptosis of ectopic endometrial cells, which leads to the occurrence and development of EMs. Full Text: PDFDOI: https://doi.org/10.5430/dcc.v5n1p9 Refbacks - There are currently no refbacks.

Discussion

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Condition tags

endometriosis

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References (12)

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last seen: 2026-06-10T17:14:06.276822+00:00
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