The Pathology of Adenomyosis

Fang Xiao, Min Xue
In: Adenomyosis · 2021 · pp. 21–26 · doi:10.1007/978-981-33-4095-4_3 · W3130654625
book-chapter OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Adenomyosis involves endometrial glands and stroma invading the myometrium, causing smooth muscle hyperplasia, though the exact cause of invasion remains unclear despite theories.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This chapter reviews the pathology and proposed pathogenesis of adenomyosis, defining it as benign penetration of endometrium into the uterine myometrium with characteristic endometrial glands and interstitial cell islands plus hyperplasia and hypertrophy of surrounding smooth muscle. It cites Cullen’s 1908 analysis of 73 consecutive cases, in which 56 were connected to the endometrium, supporting the commonly accepted idea that adenomyosis arises from endometrial glands and stroma. Although trauma to the endometrium lining is described as conducive to invasion, the chapter notes that a clear explanation is lacking for cases occurring without prior uterine surgery, and it states that why invasion occurs remains unclear with multiple theories referenced in prior material. Relevance to endometriosis: it discusses shared pathogenetic concepts and explicitly references the “pathogenetic role of stromal cells in endometriosis and adenomyosis,” though the chapter’s main focus is adenomyosis pathology.

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adenomyosis

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last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK