Hubungan Endometriosis dengan Kejadian Infertilitas Wanita di Poliklinik Obstetri dan Ginekologi RSUD Dr. Moewardi

Hubungan Endometriosis dengan Kejadian Infertilitas Wanita di Poliklinik Obstetri dan Ginekologi RSUD Dr. Moewardi DOI: https://doi.org/10.20961/plexus.v5i1.2555Keywords: cross-sectional, endometriosis, histopatologi, infertilitas, rekam medisAbstract Pendahuluan: Endometriosis merupakan penyakit sistemik kompleks di mana jaringan mirip endometrium tumbuh di luar rahim dan dapat mengganggu fungsi reproduksi. Salah satu komplikasi yang sering dikaitkan adalah infertilitas. Infertilitas memengaruhi sekitar 110 juta wanita di dunia dan meningkat sebesar 0,68% per tahun. Penelitian ini bertujuan mengetahui hubungan antara endometriosis dan infertilitas pada pasien di RSUD Dr. Moewardi. Metode: Penelitian observasional analitik dengan desain cross-sectional ini dilakukan pada 17–19 Juni 2025. Subjek adalah wanita usia reproduktif (20–45 tahun) yang telah menikah, terdiagnosis endometriosis melalui histopatologi, dan memiliki rekam medis lengkap. Sampel diambil secara purposive sampling sebanyak 50 pasien. Analisis data menggunakan uji chi-square dan perhitungan odds ratio. Hasil: Sebanyak 20 pasien (40%) terdiagnosis endometriosis dan 30 pasien (60%) tidak. Terdapat 30 pasien (60%) mengalami infertilitas dan 20 pasien (40%) tidak. Uji chi-square menunjukkan tidak ada hubungan signifikan antara endometriosis dan infertilitas (p = 0,077; OR = 3,00; CI 95%: 0,869–10,363). Analisis karakteristik menunjukkan usia memiliki perbedaan signifikan yang mungkin menjadi faktor perancu Kesimpulan: Tidak ditemukan hubungan yang signifikan secara statistik antara endometriosis dan infertilitas di RSUD Dr. Moewardi. Namun secara klinis, terdapat kecenderungan pasien dengan endometriosis memiliki risiko tiga kali lebih besar mengalami infertilitas dibandingkan pasien tanpa endometriosis. References Al-Lami, R. A., Taha, S. A., Jalloul, R. J., & Taylor, H. S. (2024). Women with endometriosis in the United States: National Survey of Family Growth, 2011–2019. Journal of Endometriosis and Uterine Disorders, 8(May), 100081. https://doi.org/10.1016/j.jeud.2024.100081 Ambildhuke, K., Pajai, S., Chimegave, A., Mundhada, R., & Kabra, P. (2022). A Review of Tubal Factors Affecting Fertility and its Management. Cureus, 14(11), 1–6. https://doi.org/10.7759/cureus.30990 Cousins, F. L., McKinnon, B. D., Mortlock, S., Fitzgerald, H. C., Zhang, C., Montgomery, G. W., & Gargett, C. E. (2023). New concepts on the etiology of endometriosis. Journal of Obstetrics and Gynaecology Research, 49(4), 1090–1105. https://doi.org/10.1111/jog.15549 Filip, L., Duică, F., Prădatu, A., Crețoiu, D., Suciu, N., Crețoiu, S. M., Predescu, D. V., Varlas, V. N., & Voinea, S. C. (2020). Endometriosis associated infertility: A critical review and analysis on etiopathogenesis and therapeutic approaches. Medicina (Lithuania), 56(9), 1–23. https://doi.org/10.3390/medicina56090460 Jørgensen, H., Hill, A. S., Beste, M. T., Kumar, M. P., Chiswick, E., Fedorcsak, P., Isaacson, K. B., Lauffenburger, D. A., Griffith, L. G., & Qvigstad, E. (2017). Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility. Fertility and Sterility, 107(5), 1191-1199.e2. https://doi.org/10.1016/j.fertnstert.2017.03.013 Liang, Y. (2024). Global, regional, and national prevalence and trends of infertility among individuals of reproductive age (15–49 years) from 1990 to 2021, with projections to 2040, Human Reproduction, 2025. Oxford University Press. https://doi.org/https://doi.org/10.1093/humrep/deae292 Liu, Y., & Zhang, W. (2017). Association between body mass index and endometriosis risk: A meta-analysis. Oncotarget, 8(29), 46928–46936. https://doi.org/10.18632/oncotarget.14916 Malvezzi, H., Hernandes, C., Piccinato, C. A., & Podgaec, S. (2019). Interleukin in endometriosis-associated infertility-pelvic pain: Systematic review and meta-analysis. Reproduction, 158(1), 1–12. https://doi.org/10.1530/REP-18-0618 Micha, R. (2017). Impact of Endometriosis on IVF Outcomes: An Evaluation of the Society for Assisted Reproductive Technologies Database. Physiology & Behavior, 176(1), 100–106. https://doi.org/10.1177/0022146515594631.Marriage Parasar, P., Ozcan, P., & Terry, K. L. (2017). Endometriosis: Epidemiology, Diagnosis and Clinical Management. Current Obstetrics and Gynecology Reports, 6(1), 34. https://doi.org/10.1007/S13669-017-0187-1 Park, W., Lim, W., Kim, M., Jang, H., Park, S. J., Song, G., & Park, S. (2025). Female reproductive disease, endometriosis: From inflammation to infertility. Molecules and Cells, 48(1), 100164. https://doi.org/10.1016/j.mocell.2024.100164 Pašalić, E., Tambuwala, M. M., & Hromić-Jahjefendić, A. (2023). Endometriosis: Classification, pathophisiology, and treatment options. Pathology Research and Practice, 251. https://doi.org/10.1016/j.prp.2023.154847 Rahayu, D. et al. (2024). pISSN:2355-7583 | eISSN:2549-4864 http://ejurnalmalahayati.ac.id/index.php/kesehatan. 11(5), 883–895. Saavalainen, L., But, A., Tiitinen, A., Härkki, P., Gissler, M., Haukka, J., & Heikinheimo, O. (2019). Mortality of midlife women with surgically verified endometriosis - A cohort study including 2.5 million person-years of observation. Human Reproduction, 34(8), 1576–1586. https://doi.org/10.1093/humrep/dez074 Tanbo, T., & Fedorcsak, P. (2017). Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstetricia et Gynecologica Scandinavica, 96(6), 659–667. https://doi.org/10.1111/aogs.13082 Vatsa, R., & Sethi, A. (2021). Impact of endometriosis on female fertility and the management options for endometriosis-related infertility in reproductive age women: a scoping review with recent evidences. Middle East Fertility Society Journal, 26(1). https://doi.org/10.1186/s43043-021-00082-3 World Health Organization. (2021). Infertility prevalence estimates. Downloads Published Issue Section License Copyright (c) 2026 Ajeng Dihade, Hermawan Udiyanto, Teguh Prakosa This work is licensed under a Creative Commons Attribution 4.0 International License. Copyright @2022. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).