Clinical and hematological improvement in a patient receiving danazol therapy for myelofibrosis with myeloid metaplasia

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Danazol therapy improved severe cytopenia, reduced myeloid metaplasia, and was well-tolerated in a patient with myelofibrosis and myeloid metaplasia.

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Abstract

We report the positive effect of danazol on clinical and hematological data in a patient with myelofibrosis and myeloid metaplasia. Severe cytopenia was corrected within 2 months and was maintained for an additional 2-month period. Myeloid metaplasia (lymph nodes and skin lesions) was greatly reduced. The patient experienced no side effects. We propose further trials to confirm the utility of this agent in this disease.

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MeSH descriptors

Danazol Pregnadienes Primary Myelofibrosis Danazol Humans Male Middle Aged Pregnadienes Primary Myelofibrosis Primary Myelofibrosis

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openalex
last seen: 2026-05-10T10:50:55.528521+00:00
pubmed
last seen: 2026-10-08T21:12:08.185882+00:00
License: CC0 · commercial use OK