Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss

Michele Q. Panzan, Rosiane Mattar, Carla Cristina Maganhin, Ricardo Santos Simões, Alexandre Guilherme Zabeu Rossi, E.L.A. Motta, Edmund Chada Baracat, José Maria Soares
In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 2012 · vol. 167(1) , pp. 47–52 · doi:10.1016/j.ejogrb.2012.10.021 · PMID:23218678 · W1971265723
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This study investigated FAS and caspase-3 expression in endometrial tissue from patients with idiopathic infertility and recurrent pregnancy loss to understand their potential role in these conditions.

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Abstract

ObjectiveTo investigate expression of BcL-2, FAS, FAS ligand (FASL) and cleaved caspase-3 in the endometrial tissue of women with idiopathic infertility (with two consecutive failed cycles of in vitro fertilization) and women with idiopathic recurrent pregnancy loss. The control group consisted of fertile women.Study designEndometrial tissue samples from fertile women (n=25), women with idiopathic infertility (n=25) and women with idiopathic recurrent pregnancy loss (n=25) were collected on the seventh or eighth postovulatory day of their menstrual cycles for evaluation. Expression of BcL-2, FAS, FASL and cleaved caspase-3 was assessed using immunohistochemical methods.ResultsExpression of BcL-2 and FAS was significantly higher and lower, respectively, in the women with idiopathic infertility than in the other groups (p<0.01). Expression of cleaved caspase-3 was significantly lower in the women with idiopathic infertility than in the other groups (p<0.01). Expression of FASL was similar in all three groups.ConclusionDisturbances in endometrial apoptosis may be a contributing factor in patients with idiopathic infertility and recurrent pregnancy loss.

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