Chemokines and Gynecologic Malignancies

Rupert Negus, Frances R. Balkwill
In: Chemokines and Cancer · 1999 · pp. 193–205 · doi:10.1007/978-1-59259-701-7_11 · W66875714
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This chapter reviews chemokine expression in ovarian carcinoma leukocyte infiltrates, focusing on monocyte chemoattractant protein-1 regulation while noting their presence in endometriosis.

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Abstract

Gynecologic malignancies consist of tumors of the ovary, cervix, and uterus. Little is known of the role of chemokines in carcinoma of the cervix or endometrium, although they are expressed in conditions such as endometriosis (1). This chapter reviews the expression of chemokines in carcinoma of the ovary in the context of the leukocyte infiltrate associated with this tumor. Most work to date concerns monocyte chemoattractant protein-1 (MCP-1). The expression of this chemokine is considered in more detail, and some of the mechanisms by which its production may be regulated in vivo are discussed.KeywordsOvarian CancerNatural Killer CellOvarian CarcinomaHuman Ovarian CancerChemotactic ActivityThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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endometriosis

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