Multiple extrauterine adenomyomas and uterus-like masses: case reports and review of the literature

Silvestro Carinelli, F. Motta, Francesca Motta, Giada Frontino, Elisa Restelli, Luigi Fedele
Fertility and sterility · 2009 · vol. 91(5) , pp. 1956.e9–1956.e11 · doi:10.1016/j.fertnstert.2009.01.076 · PMID:19254794 · W1987791111
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This paper presents case reports and a literature review of multiple extrauterine adenomyomas and uterus-like masses.

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Abstract

OBJECTIVE: To describe two rare cases of multiple extrauterine adenomyomas, their clinical management, and their response to surgical and hormone therapy with GnRH agonist. DESIGN: Case report and review of the English-language scientific literature. SETTING: Cases presented in a tertiary health care academic institution. PATIENT(S): Two patients without urogenital malformations diagnosed with extrauterine adenomyoma, which is a benign tumor composed of smooth muscle and endometrium, typically originating within the uterus. INTERVENTION(S): Surgical radical excision of adenomyomas followed by a long-term hormone therapy with GnRH agonist. MAIN OUTCOME MEASURE(S): Anatomical and clinical outcomes. RESULT(S): Surgical treatment followed by long-term GnRH agonist therapy appeared effective in keeping the disease stable. After a long-term follow-up of 10 and 4 years, the two patients are still asymptomatic and stable. CONCLUSION(S): Only 19 other cases of extrauterine adenomyomas are reported in the English-language scientific literature, and no cases of multiple masses are described until now. It is probable that these extrauterine adenomyomas arose from a metaplastic transformation of the subcelomic mesenchyme. Long-term GnRH agonist therapy after surgery appeared effective in keeping the disease stable.

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MeSH descriptors

Adenomyoma Intestinal Neoplasms Uterus Adenomyoma Adenomyoma Adult Combined Modality Therapy Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Intestinal Neoplasms Intestinal Neoplasms Middle Aged Uterus

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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