Effects of Tamoxifen and Other SERMs in the Endometrium and Follow-Up of Patients

In: Uterine Cancer · 2015 · pp. 437–441 · doi:10.1007/978-81-322-1892-0_41 · W2466849138
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Selective estrogen receptor modulators like tamoxifen are common hormonal agents for breast cancer, acting as competitive inhibitors of estrogen receptors with varied effects depending on tissue.

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This chapter reviews the effects of tamoxifen and other selective estrogen receptor modulators (SERMs) on the endometrium, in the context of hormone therapy for estrogen receptor–positive breast cancer. It summarizes evidence from prospective and randomized studies that monitored endometrial changes using approaches such as office endometrial biopsy, transvaginal ultrasound, and correlating imaging with endometrial pathology, reporting associations with endometrial thickness and increased endometrial hyperplasia/cancer risk in tamoxifen-treated patients. The chapter’s limitation is that it functions as a narrative overview rather than presenting new original data. Relevance to endometriosis: endometriosis is not the focus of the chapter; however, it discusses estrogen receptor modulation and uterine/endometrial effects of SERMs that are mechanistically adjacent to endometriosis research, though no direct endometriosis outcomes are described.

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Abstract

Hormone therapy remains an integral part of the treatment of hormone receptor-positive breast cancers. Tamoxifen, a selective estrogen receptor modulator, is the most common hormonal agent used in this scenario. Selective estrogen receptor modulators (SERMs) are competitive inhibitors of estrogen receptors which have an estrogen agonist and antagonist effect depending on target tissues. The antiestrogenic effect is by blocking the binding of estrogen to estrogen receptors. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

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Keywords

- Endometrial Cancer - Breast Cancer Mortality - Selective Estrogen Receptor Modulator - Endometrial Thickness - Endometrial Hyperplasia These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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