Blockade of LHRH-induced lordosis by α- and β-adrenergic antagonists in ovariectomized, estrogen primed rats

Gabriela González‐Mariscal, Carlos Beyer
In: Pharmacology Biochemistry and Behavior · 1988 · vol. 31(3) , pp. 573–577 · doi:10.1016/0091-3057(88)90232-8 · PMID:3075044 · W2011278119
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher

Abstract

The participation of a noradrenergic mechanism in the facilitation of lordosis by luteinizing hormone-releasing hormone (LHRH) was studied in two groups of ovariectomized estrogen primed rats, with or without sexual experience. The administration of 5 micrograms estradiol benzoate (EB) alone to sexually inexperienced subjects (Ss) induced weak lordosis behavior in some of them (mean lordosis quotient, LQ = 12 +/- 19). The SC injection of 5 micrograms LHRH significantly increased this response four hours later (LQ = 38 +/- 41), though great variability was observed (59% of Ss showing LQs below 30). The systemic administration of either prazosin, an alpha-adrenergic antagonist (0.2 or 1 mg/kg), or propranolol, a beta-adrenergic antagonist (20 mg/kg), totally suppressed LHRH-induced lordosis in sexually inexperienced Ss (mean LQs = 8 +/- 11; 5 +/- 10; 18 +/- 31, respectively). In sexually experienced Ss (tested on two previous occasions with EB and LHRH) the administration of EB alone on a third test induced significant levels of lordosis (mean LQ = 51 +/- 41). The administration of 5 micrograms LHRH to sexually experienced, estrogen primed Ss induced near maximal levels of lordosis (LQ = 94 +/- 18). In these Ss, prazosin (0.2 and 1 mg/kg) and, to a lesser extent, propranolol (20 mg/kg) significantly depressed lordosis to values that were not significantly different from those obtained after EB alone (mean LQs = 59 +/- 38; 63 +/- 20; 74 +/- 32, respectively). These results indicate that blockade of noradrenergic transmission by either alpha- or beta-antagonists counteracts the stimulatory effect of LHRH on lordosis in ovariectomized estrogen primed rats with or without sexual experience.(ABSTRACT TRUNCATED AT 250 WORDS)

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

References (32)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK