Prevention of progesterone-induced lordosis behavior by alpha or beta adrenergic antagonists in ovariectomized estrogen-primed rats

Alonso Fernández‐Guasti, Kjerstin Larsson, Carlos Beyer
In: Pharmacology Biochemistry and Behavior · 1985 · vol. 22(2) , pp. 279–282 · doi:10.1016/0091-3057(85)90391-0 · PMID:2858869 · W2015181553
article OA: closed CC0 ⤵ 3 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-19 ⓘ

Alpha and beta adrenergic antagonists dose-dependently reduced progesterone-induced lordosis in estrogen-primed rats without affecting estrogen-induced behavior, indicating that adrenergic neurons modulate this reproductive response rather than forming part of the reflex arc.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The effect of systemic administration of adrenergic alpha (phenoxybenzamine and prazosin) and beta (propranolol) antagonists on the lordosis behavior induced by progesterone (2.0 mg/rat) was studied in ovariectomized estradiol benzoate (4.0 micrograms/rat) primed rats. The effect of these antagonists was also tested on the lordosis behavior induced in ovariectomized rats by estradiol benzoate alone (1.25 micrograms/rat each two days). Phenoxybenzamine (0.8, 4.0 and 20.0 mg/kg), propranolol (0.8, 4.0 and 20.0 mg/kg) and prazosin (0.2 and 1.0 mg/kg) caused a dose-dependent reduction of progesterone induced lordosis. By contrast, phenoxybenzamine (4.0 mg/kg), propranolol (4.0 mg/kg) or prazosin (1.0 mg/kg) did not affect estrogen induced lordosis behavior. Results suggest the following conclusions: (1) blockage of either alpha or beta adrenoreceptors prevents progesterone induced lordosis behavior and (2) the adrenergic neuron involved in progesterone facilitation of lordosis behavior is not a part of the reflex arc for lordosis but probably modulates the activity of this system.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

Cited by (3)

References (25)

Cited by (3)

SciLite annotations

chemicals 18
progesterone estrogen phenoxybenzamine prazosin propranolol progesterone estriol acetate benzoate estriol acetate benzoate phenoxybenzamine propranolol prazosin progesterone phenoxybenzamine propranolol prazosin estrogen progesterone progesterone
organisms 5
rattus sp. zitter rats zitter rats rattus sp. rattus sp.

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
scilite
last seen: 2026-05-18T04:57:49.680383+00:00
unpaywall
last seen: 2026-08-31T06:25:10.444339+00:00
License: CC0 · commercial use OK