N-acetyl Transferase 2 Gene Polymorphisms in Patients with Endometriosis.

Objective : To explore the association of the N-acetyl transferase 2 (NAT 2) gene polymorphisms with endometriosis. Methods : One hundred seventy-two women with surgically or histologically diagnosed endometriosis of stages I-IV, and 205. patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Genotype distribution of NAT 2 polymorphisms and frequencies of slow and fast acetylators in affected women and controls were evaluated. Results : There was no statistically significant difference in the genotype distribution of NAT 2 polymorphisms and frequencies of slow and fast acetylators between the patients with endometriosis and the controls. Conclusion : These results suggest that N-acetyl transferase 2 gene polymorphisms is not associated with the risk for endometriosis in the Korean population.