Profiling of serum IgG1 Fc‑glycosylation and tissue bisecting GlcNAc in adenomyosis

Meixian Wang, Wang M, Cao C, Cuiyan Cao, Binqi Rui, Rui B, Lei Wang, Wang L, Yu L, Long Yu, Ming Li, Li M, Yan J, Jingyu Yan, Shao X, Xiaoguang Shao
Journal of reproductive immunology · 2026 · vol. 176 , pp. 104934 · doi:10.1016/j.jri.2026.104934 · PMID:42424966 · W7167484484
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher

Abstract

Adenomyosis (AM) commonly affects women of reproductive age and can impair female fertility, yet its diagnosis and pathogenesis remain challenging. We compared serum IgG1 Fc‑glycosylation profiles between AM patients (n = 30) and non‑AM controls (n = 16). IgG concentrations were quantified, followed by liquid chromatography‑mass spectrometry (LC‑MS) based comparative analysis of IgG1 glycoform differences. Distinct IgG glycoform variations emerged between the two groups. The AM cohort exhibited a significant reduction in bisecting N-acetylglucosamine( GlcNAc) modifications alongside elevated sialylation levels relative to controls. Furthermore, we performed tissue staining on adenomyosis tissues using lectin and found that the bisecting glycans in the lesion tissue were also lower than those in the control group. To our knowledge, this study provides the first comprehensive characterization of serum IgG glycosylation profiles in AM. The identified alterations in bisecting GlcNAc levels offer novel molecular‑level insights into the pathophysiology of AM and hold promise as potential diagnostic signatures.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (35)

SciLite annotations

organisms 1
noordeloos 2009062
chemicals 3
withalongolide n glucosamine oligosaccharide glycan

Source provenance

europepmc
last seen: 2026-07-17T06:14:45.765109+00:00
openalex
last seen: 2026-07-17T06:06:56.645705+00:00
pubmed
last seen: 2026-07-17T06:09:02.161223+00:00
scilite
last seen: 2026-07-12T09:48:33.364277+00:00
License: CC0 · commercial use OK