Sonography and Magnetic Resonance Imaging for the Diagnosis of Adenomyosis: Comparison with Histopathology

Asra Anjum, Salma Umbreen, Muhammad Nadeem, Fouzia Noreen, Fareena Asim, Saba Anwar
In: Journal of Islamabad Medical & Dental College · 2025 · vol. 13(4) , pp. 638–645 · doi:10.35787/jimdc.v13i4.1030 · W4406105449
article OA: diamond CC0 ⤵ 1 in-corpus citation
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study validated sonography and MRI against histopathology for adenomyosis diagnosis, finding sonography had higher sensitivity but MRI demonstrated superior specificity and accuracy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ABSTRACT Introduction: Modern magnetic resonance imaging (MRI) and transvaginal ultrasound techniques have significantly improved the ability to diagnose adenomyosis with a high level of accuracy. This enables healthcare professionals to administer customized treatments that target this specific disease condition. Objectives: To assess the accuracy of sonography and MRI in identifying adenomyosis, with histopathology serving as the reference standard for comparison i.e. the gold standard. Study Design: a cross-sectional validation design Setting: The Department of Diagnostic Radiology/ Pathology, POF Hospital / Wah Medical College, Wah Cantt. Duration of Study: From August, 2018, to August, 2019. Subjects and Methods: The patients who underwent surgical treatment in the relevant department were included in the study. Tissue samples obtained from these patients were subjected to histopathological analysis, which was interpreted by a consultant pathologist. The sonographic and MRI findings were subsequently compared to the histopathology report for each patient. Results: The mean age of the enrolled patients in the study was 38.3±5.5 years. Specificity, Sensitivity, negative predictive value, positive predictive value, and diagnostic accuracy of sonography and MRI was calculated by taking histopathology as gold standard and found to be 92.1%, 88.0%, 95.8%, 78.5%, and 91.0% respectively for sonography and 96.0%, 84.0%, 94.8%, 87.5%, and 93.0% respectively for MRI. Conclusion: Sensitivity of sonography remained to be high as compared to MRI in present study while specificity and accuracy of MRI remained to be high from sonography. It is necessary to observe the unusual and usual characteristics of adenomyosis for further improvements in diagnostic outcomes.
Full text 2,362 characters · extracted from oa-doi-fallback · 4 sections · click to expand

Abstract

Introduction: Modern magnetic resonance imaging (MRI) and transvaginal ultrasound techniques have significantly improved the ability to diagnose adenomyosis with a high level of accuracy. This enables healthcare professionals to administer customized treatments that target this specific disease condition.

Objectives

To assess the accuracy of sonography and MRI in identifying adenomyosis, with histopathology serving as the reference standard for comparison i.e. the gold standard. Study Design: a cross-sectional validation design Setting: The Department of Diagnostic Radiology/ Pathology, POF Hospital / Wah Medical College, Wah Cantt. Duration of Study: From August, 2018, to August, 2019. Subjects and Methods: The patients who underwent surgical treatment in the relevant department were included in the study. Tissue samples obtained from these patients were subjected to histopathological analysis, which was interpreted by a consultant pathologist. The sonographic and MRI findings were subsequently compared to the histopathology report for each patient.

Results

The mean age of the enrolled patients in the study was 38.3±5.5 years. Specificity, Sensitivity, negative predictive value, positive predictive value, and diagnostic accuracy of sonography and MRI was calculated by taking histopathology as gold standard and found to be 92.1%, 88.0%, 95.8%, 78.5%, and 91.0% respectively for sonography and 96.0%, 84.0%, 94.8%, 87.5%, and 93.0% respectively for MRI.

Conclusion

Sensitivity of sonography remained to be high as compared to MRI in present study while specificity and accuracy of MRI remained to be high from sonography. It is necessary to observe the unusual and usual characteristics of adenomyosis for further improvements in diagnostic outcomes. Downloads Published Issue Section License This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK