Matrix Metalloproteinases as Biomarkers of Endometriosis and the Role of Progesterone Receptors
This review explores studies on matrix metalloproteinases (MMPs) and endometriosis, examining their role in disease development and potential as non-invasive diagnostic biomarkers.
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This paper is a review of studies investigating whether matrix metalloproteinases (MMPs) and progesterone receptor signaling are associated with endometriosis, focusing on PubMed-identified reports of altered MMP expression in patient samples and of mechanisms linking MMP activity to endometriotic lesion formation and invasion. Across the cited studies, elevated MMP-9 and other MMPs (e.g., MMP-2, MMP-3) were reported in peritoneal fluid, serum, and ascites, with findings that MMP levels relate to clinical stage, proliferation, inflammation, infertility, and the disturbed balance between MMPs and inhibitors such as TIMP-1; one study also reported an MMP-9 cutoff with sensitivity/specificity for severe disease. A limitation explicitly acknowledged by the review’s framing is that prior biomarker studies have produced scattered results and indecisive correlations, and the review does not provide a definitive non-invasive biomarker panel. Relevance to endometriosis: the paper is centrally about endometriosis—reviewing MMP expression as potential diagnostic biomarkers and describing how progesterone receptor (PR-A/PR-B) imbalance may regulate MMP-2 and MMP-9 in the disease context.
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References (15)
- Curcumin as anti-endometriotic agent: Implication of MMP-3 and intrinsic apoptotic pathway via openalex
- Increased Circulating MMP-2 Levels in Infertile Patients With Moderate and Severe Pelvic Endometriosis via openalex
- Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model via openalex
- Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis via openalex
- Matrix metalloproteinases 3 polymorphism increases the risk of developing advanced endometriosis and infertility: A case-control study via openalex
- Matrix Metalloproteinases and Endometriosis via openalex
- Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis via openalex
- Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies via openalex
- The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review) via openalex
- The Effect of Imbalanced Progesterone Receptor-A/-B Ratio on Gelatinase Expressions in Endometriosis via openalex
- The levels of matrix metalloproteinase-9 and neutrophil gelatinase-associated lipocalin in different stages of endometriosis via openalex
- W2796429112 via openalex
- W2016431623 via openalex
- W2410880911 via openalex
- W2122365868 via openalex
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