Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization

Peng-Hui Wang, Wang PH, Wen-Yuann Shyong, Shyong WY, Chi-Hung Lin, Lin CH, Chen YJ, Yann-Jang Chen, Ywan Feng Li, Li YF, Hsiang-Tai Chao, Chao HT, Chiou-Chung Yuan, Yuan CC
Analytical and quantitative cytology and histology · 2002 · PMID:11865944
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Comparative genomic hybridization of 25 adenomyosis cases revealed no recurrent copy number alterations, suggesting genetic changes may be rare or below CGH detection limits.

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Abstract

OBJECTIVE: To use comparative genomic hybridization (CGH) to analyzefrozen tissuesfrom adenomyosis cases to discover and map genomic regions for chromosomal gains and losses. STUDY DESIGN: In a retrospective study, upper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings. RESULTS: No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis. CONCLUSION: Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Chromosome Aberrations DNA Endometriosis Uterine Diseases DNA Endometriosis Endometriosis Endometriosis Female Gene Dosage Humans Image Processing, Computer-Assisted Karyotyping Nucleic Acid Hybridization Retrospective Studies Uterine Diseases Uterine Diseases Uterine Diseases

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europepmc
last seen: 2026-08-19T06:08:28.815611+00:00
pubmed
last seen: 2026-05-13T22:13:13.417725+00:00
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