Vitamin D can ameliorate premature ovarian failure by inhibiting neutrophil extracellular traps: A review

Menglu Chen, Lailai Li, Yihui Chai, Yuqi Yang, Sibu Ma, Xiang Pu, Yunzhi Chen
In: Medicine · 2023 · vol. 102(13) , pp. e33417 · doi:10.1097/md.0000000000033417 · PMID:37000081 · W4362469169
review OA: gold CC0 ⤵ 3 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This review theorizes that Vitamin D ameliorates premature ovarian failure by inhibiting neutrophil extracellular traps and intervening in inflammatory, immune, oxidative stress, and fibrotic responses.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The etiology of premature ovarian failure (POF) is mainly related to inflammatory diseases, autoimmune diseases, and tumor radiotherapy and chemotherapy; however, its specific pathogenesis has not been clarified. Vitamin D (VD), a fat-soluble vitamin, is an essential steroid hormone in the human body. Neutrophil extracellular traps (NETs) are meshwork structures that are formed when neutrophils are stimulated by inflammation and other factors and are closely associated with autoimmune and inflammatory diseases. Notably, VD inhibits NET formation and intervenes in the development of POF in terms of inflammatory and immune responses, oxidative stress, and tissue fibrosis. Therefore, this study aimed to theorize the relationship between NETs, VD, and POF and provide new ideas and targets for the pathogenesis and clinical treatment of POF.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

Cited by (3)

References (60)

Cited by (3)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK