Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health

Edouard Mills, Waljit S. Dhillo
Journal of neuroendocrinology · 2022 · vol. 34(10) , pp. e13201 · doi:10.1111/jne.13201 · PMID:36262016 · W4296185557
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This review discusses the roles of kisspeptin and neurokinin B in reproduction and explores their potential as novel therapeutic strategies for reproductive disorders.

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Abstract

The reproductive neuropeptide kisspeptin has emerged as the master regulator of mammalian reproduction due to its key roles in the initiation of puberty and the control of fertility. Alongside the tachykinin neurokinin B and the endogenous opioid dynorphin, these peptides are central to the hormonal control of reproduction. Building on the expanding body of experimental animal models, interest has flourished with human studies revealing that kisspeptin administration stimulates physiological reproductive hormone secretion in both healthy men and women, as well as patients with common reproductive disorders. In addition, emerging therapeutic roles based on neurokinin B for the management of menopausal flushing, endometriosis and uterine fibroids are increasingly recognised. In this review, we focus on kisspeptin and neurokinin B and their potential application as novel clinical strategies for the management of reproductive disorders.

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Condition tags

endometriosis

MeSH descriptors

Kisspeptins Kisspeptins Kisspeptins Kisspeptins Neurokinin B Neurokinin B Neurokinin B Neurokinin B Animals Animals Animals Biology Biology Biology Dynorphins Dynorphins Dynorphins Female Female Female

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europepmc
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openalex
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