High levels of CA125 (over 1,000 IU/ml) in patients with gynecologic disease and no malignant conditions: three cases and literature review
Three cases of benign gynecologic conditions (uterine myoma and endometrioma) presented with CA125 levels over 1,000 IU/ml, highlighting the need for auxiliary data in differential diagnosis.
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This paper reports three clinical cases in which women with benign gynecologic conditions and pelvic masses had very high serum CA125 levels (>1,000 IU/ml), initially leading to concern for ovarian cancer or leiomyosarcoma. Using clinical data from Vali-Asr hospital and subsequent histologic findings after laparotomy, the authors found uterine myoma in two cases and endometrioma in one case. The main conclusion is that CA125 levels above 1,000 IU/ml can occur in non-malignant gynecologic disease, and differential diagnosis should consider other clinical and imaging information. Relevance to endometriosis: an endometrioma case with very high CA125 is presented as one of the three patients, and the paper’s literature discussion includes prior reports of elevated CA125 in endometriosis.
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- last seen: 2026-08-23T09:30:01.253652+00:00
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