{"paper_id":"70d4ed78-2999-43f2-a353-e1a6fa02767e","body_text":"Abstract\nObjective\nTo report the very high serum levels of CA125 in patients with benign gynecologic disease which manifests as pelvic mass.\nMethods\nClinical data of three cases with high levels of CA125 over 1,000 IU/ml and benign gynecologic conditions were gathered. in Vali-Asr hospital.\nResults\nThree patients were scheduled for laparatomy as ovarian cancer and leiomyosarcoma. Histologic results after laparatomy showed uterine myoma in two patients and endometrioma in a third patient.\nConclusion\nHigh levels of CA125 over 1,000 IU/ml, may be showed in other gynecologic conditions with no malignancy. So, other clinical and imaging data could be helpful for differential diagnosis of these patients.\nSimilar content being viewed by others\nReferences\nBast RC Jr, Badgwell D, LuZ, Marquez R et al (2005) New tumor markers: CA125 and beyond Int J Gynecol Cancer 15(3):274–281\nDiamandis EP, Scorials A, Facchioli S et al (2003) Human kallikrein 6 (hK6): A new potential biomarker for diagnosis and prognosis of ovarian carcinoma. J Clin Oncol 21:1035–1043\nLi HJ, Shen K, Lang JH, Wu M, Hung HF et al (2003) Benign ovarian tumor with ascitis and high serum levels of CA125: report of 3 casess. Zhanghua FU Chun Ke Za Zhi 38(3):147–149\nShian CS, Chang MY, Chiang CH, Hsieh CC, Hsich TT (2003) Ovarian endometrioma associated with very high serum CA125 levels. Chang Gung Med J 26(9):695–699\nPhupong V, Chen O, Ultchaswadi P (2004) High level of CA125 due to large endometrioma. J Med Assoc Thai 87(9):1108–1111\nNikolic B, Mitrovic A, Lazic J (2006) Mean of CA125 in making therapy decisison in adnexal inflammatory tumors. Bosn J Basic Med SCI 6(2):3–96\nChamande SA, Eleonu B, Hamid AM (1996) High levels of CA125 in a case of a parasitic leiomyoma presenting as an abdominal mass. Gynecologic Oncology 61(2):297–298\nVieira SC, Pimental LH, Ribrro JC, de Andrade Note AF, de Santana Jo (2003) Meigs syndrome with elevated CA125:case report. Sao Paulo Med J 121(5):21–22\nDawood MY, Khan Dawood FS (1994) Plasma insulin like growth factor-I, Ca125, estrogen, progesterone in women with leiomyomas. Fertil Stril 61:617–621\nvander Spuy ZM, Wood M, Freggen G, Salie Hendricks M (1993) Serum CA125 concentration in women with endometriosis or uterine fibroids treated with GNRH-agonists analogues. S Afr Med J 83:510–513\nMehmet Yilmazer, Murat Sonmezer, Mete Gungor, Veysel Fenkci, Serhan Cevrioglu (2003) Unusually elevated serum carbohydrate antigen 125 (Ca125) and CA19-9 levels as a result of unruptured bilateral endometrioma. Aust NZ J Obstet Gynaecol 43(4):329\nJohansson J, Santala M, Kauppila A (1998) Explosive rise of serum CA125 following the rupture of ovarian endometrioma. Hum Reprod 13:3503–3504\nKashyap RJ (1999) Extremely elevated serum CA125 due to endometriosis. Aust NZ J Obstet Gynaeco l39:269–270\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nGhaemmaghami, F., Karimi Zarchi, M. & Hamedi, B. High levels of CA125 (over 1,000 IU/ml) in patients with gynecologic disease and no malignant conditions: three cases and literature review. Arch Gynecol Obstet 276, 559–561 (2007). https://doi.org/10.1007/s00404-007-0381-x\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-007-0381-x","source_license":"public-domain-us","license_restricted":false}