Precocious Puberty and the Lin28/Let7 Pathway: The Therapeutic Effect of the Nourishing “Yin” and Purging “Fire” Traditional Chinese Medicine Mixture in a Rat Model

Yuanyuan He; Xinghui Han; Wen Sun; Jian Yu; Amin Tamadon

doi:10.1155/2018/4868045

Precocious Puberty and the Lin28/Let7 Pathway: The Therapeutic Effect of the Nourishing “Yin” and Purging “Fire” Traditional Chinese Medicine Mixture in a Rat Model

Yuanyuan He, Xinghui Han, Wen Sun, Jian Yu, Amin Tamadon

In: Evidence-Based Complementary and Alternative Medicine · 2018 · vol. 2018(1) , pp. 4868045 · doi:10.1155/2018/4868045 · PMID:30046338 · W2810654237

article OA: hybrid CC0 ⤵ 3 in-corpus citations

📄 Open PDF View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated the Lin28/Let7 pathway's role in precocious puberty and found that a Traditional Chinese Medicine mixture inhibited Lin28 expression and delayed puberty onset in a rat model.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

gene in the hypothalamus and the onset of puberty.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

Cited by (3)

References (73)

Effect of nourishing “Yin”-removing “Fire” Chinese herbal mixture on hypothalamic kisspeptin expression in female precocious rats via openalex
[Effects of Nourishing Yin Removing Fire Chinese Herbs on Gene Expression of Hypothalamic Ghrelin and its Receptor in Female Precocious Rats]. via openalex
Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: Therapeutic effects of nourishing "Yin"- removing "Fire" Chinese herb mixture via openalex
Induction of true precocious puberty by neonatal treatment with danazol in female rats via openalex
doi:10.1016/j.gene.2006.07.011 via openalex
doi:10.4161/rna.4.1.4364 via openalex
doi:10.1016/j.ajhg.2010.03.010 via openalex
doi:10.1016/s1567-133x(03)00140-6 via openalex
doi:10.1016/j.cell.2009.08.002 via openalex
doi:10.1038/srep11208 via openalex
doi:10.1016/j.cub.2007.03.043 via openalex
doi:10.1016/s0009-8981(03)00238-9 via openalex
doi:10.1210/en.2005-1136 via openalex
W2053085720 via openalex
doi:10.1038/ng.593 via openalex
doi:10.1155/2015/157846 via openalex
doi:10.1016/j.gene.2014.12.021 via openalex
doi:10.1016/j.jneumeth.2012.05.033 via openalex
doi:10.1016/j.neuroscience.2009.12.053 via openalex
doi:10.1007/bf02935023 via openalex
doi:10.1186/1756-0500-4-363 via openalex
doi:10.1038/ng.385 via openalex
doi:10.1155/2016/9389028 via openalex
doi:10.3945/jn.116.231076 via openalex
doi:10.1186/1471-2431-8-27 via openalex
doi:10.1016/s0092-8674(00)81906-6 via openalex
doi:10.1038/ng.382 via openalex
doi:10.1530/eje-12-0669 via openalex
doi:10.1530/joe-15-0360 via openalex
doi:10.1093/hmg/ddx246 via openalex
W2372419497 via openalex
W2412493373 via openalex
W3201570385 via openalex
W7011932143 via openalex
doi:10.1016/j.tranon.2017.09.008 via openalex
doi:10.1210/endo.139.6.6057 via openalex
doi:10.1016/j.jep.2003.09.018 via openalex
doi:10.1016/j.mad.2013.04.006 via openalex
doi:10.1152/ajpendo.00517.2010 via openalex
doi:10.1016/s0084-3954(08)70076-9 via openalex
doi:10.1542/peds.99.4.505 via openalex
doi:10.1002/jcla.22200 via openalex
doi:10.1016/j.jtcm.2018.01.005 via openalex
doi:10.1038/srep15683 via openalex
doi:10.1111/jcmm.12846 via openalex
doi:10.1038/ng.125 via openalex
doi:10.1016/j.jep.2017.05.006 via openalex
doi:10.1038/ng.2387 via openalex
doi:10.1038/ng.383 via openalex
doi:10.1186/s12958-017-0254-5 via openalex
doi:10.1016/j.mce.2012.10.025 via openalex
doi:10.1038/ng.714 via openalex
doi:10.1016/j.ctim.2014.01.002 via openalex
doi:10.1155/2014/217424 via openalex
doi:10.1038/ng.3841 via openalex
doi:10.1542/peds.2008-2491 via openalex
doi:10.1210/en.2012-2006 via openalex
doi:10.1210/en.139.6.2818 via openalex
doi:10.1016/s0012-1606(03)00126-x via openalex
doi:10.1007/978-3-319-32004-5_3-1 via openalex
doi:10.1038/ng.3097 via openalex
doi:10.1371/journal.pone.0187205 via openalex
doi:10.3345/kjp.2012.55.10.388 via openalex
doi:10.1038/pr.2016.107 via openalex
doi:10.1158/0008-5472.can-10-2388 via openalex
doi:10.1007/bf02935474 via openalex
doi:10.1038/ng.3940 via openalex
doi:10.1038/ng.386 via openalex
doi:10.1210/endo.130.1.1727719 via openalex
doi:10.1095/biolreprod.111.098442 via openalex
doi:10.1016/j.cell.2011.10.039 via openalex
doi:10.1248/bpb.b14-00064 via openalex
doi:10.1542/peds.2005-0012 via openalex

Cited by (3)

Source provenance

openalex: last seen: 2026-05-14T06:04:04.317202+00:00

License: CC0 · commercial use OK

[1] Induction of true precocious puberty by neonatal treatment with danazol in female rats 1993

[2] Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: Therapeutic effects of nourishing "Yin"- removing "Fire" Chinese herb mixture 2005

[3] Effect of nourishing “Yin”-removing “Fire” Chinese herbal mixture on hypothalamic kisspeptin expression in female precocious rats 2009

[4] [Effects of Nourishing Yin Removing Fire Chinese Herbs on Gene Expression of Hypothalamic Ghrelin and its Receptor in Female Precocious Rats]. 2015