Expression of endothelial nitric oxide synthase in the uterus of patients with leiomyoma or adenomyosis

Na-Jung Oh, Na‐Jung Oh, Ki-Young Ryu, Ki‐Young Ryu, Cha-Nam Jung, Cha‐Nam Jung, Sang Yeop Yi, Se-Ryun Kim, Se‐Ryun Kim
Journal of Obstetrics and Gynaecology Research · 2012 · vol. 39(2) , pp. 536–542 · doi:10.1111/j.1447-0756.2012.01980.x · PMID:22925111 · W1914756899
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Endothelial nitric oxide synthase expression was significantly higher in the uteri of patients with leiomyoma or adenomyosis compared to controls, and was associated with menorrhagia and dysmenorrhea.

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Abstract

AIM: To confirm the difference in the expression of endothelial nitric oxide synthase in the normal endometrium and myometrium of women who have leiomyoma or adenomyosis compared with controls, and its correlation with the pathogenesis of menorrhagia or dysmenorrhea in patients with uterine leiomyoma. METHODS: Fifty-one hysterectomized patients were divided into three groups: (i) patients with leiomyoma (n=24); (ii) those with adenomyosis (n = 19); and (iii) the control group (n=8). The expression of endothelial nitric oxide synthase was confirmed on immunohistochemistry and analyzed using an evaluation nomogram. RESULTS: The expression of endothelial nitric oxide synthase was significantly higher in the leiomyoma group and the adenomyosis group as compared with the control group. In the subgroup analysis of leiomyoma depending on symptoms (menorrhagia or dysmenorrhea or both), the expression of endothelial nitric oxide synthase was significantly higher in the symptomatic subgroup than the asymptomatic subgroup (endometrium P=0.0029, myometrium P=0.0276). CONCLUSIONS: Based on the findings that the expression of endothelial nitric oxide synthase was significantly higher in the uterus with leiomyoma or adenomyosis, it can therefore be inferred that nitric oxide might have a pathological effect on the uterus with the above diseases. In particular, it is also presumed that endothelial nitric oxide synthase is closely associated with menorrhagia and dysmenorrhea.

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Condition tags

mesh:D004412adenomyosisdysmenorrhea

MeSH descriptors

Adenomyosis Gene Expression Regulation, Enzymologic Leiomyoma Nitric Oxide Synthase Type III Uterine Neoplasms Uterus Adenomyosis Adenomyosis Adenomyosis Adult Dysmenorrhea Dysmenorrhea Endometrium Endometrium Endometrium Female Humans Hysterectomy, Vaginal Leiomyoma Leiomyoma

Citation neighborhood

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