Extending the coincubation time of gametes improves in vitro fertilization.

OA: closed ⤵ 1 in-corpus citation
AI-generated summary by claude@2026-06+body, 2026-06-13

This study investigated the effects of extending the gamete coincubation time on in vitro fertilization success and found that longer incubation periods improved outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text

This short clinical assisted reproduction paper examines whether extending the coincubation time of sperm and oocytes in IVF affects fertilization outcomes. It draws on prior studies comparing standard versus shortened sperm–oocyte exposure and reports an overall pattern in which longer coincubation time is associated with improved IVF outcomes, rather than harm to embryo development. A key caveat is that the evidence it discusses is based on heterogeneous prior experiments and varying protocols, so differences in study design and timing may limit generalizability. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 4,150 characters · extracted from oa-doi-fallback · click to expand
REFERENCES Krausz C, Mills C, Rogers S, Tan SL, Aiken RJ: Stimulation of oxidant generation by human sperm suspensions using phorbol esters and formyl peptides: Relationships with motility and fertilization in vitro. Fertil Steril 1994;62:599-605 Nasr-Esfahani MH, Aitken RJ, Johnson MH: Hydrogen peroxide levels in mouse oocytes and early cleavage stage embryos developed in vitro or in vivo. Development 1990;109:501-507 Coskun S, Roca GL, Elnour AM, Mayman HAL, Hollanders JMG, Jaroudi KA: Effects of reducing insemination time in human in vitro fertilization and embryo development by using sibling oocytes. J Assist Reprod Genet 1998;15:605-608 Kochhar HPS, Buckrell BC, Pollard JW, King WA: Cleavage, sex and cell number of ovine embryos developed after different sperm-oocyte co-incubation intervals. Theriogenology 1999;51:322 Aitken RJ, Buckingham DW, West K, Brindle J: On the use of paramagnetic beads and ferrofluids to assess and eliminate the leukocytic contribution to oxygen radical generation by human sperm suspensions. Am J Reprod Immunol 1996;35:541-551 Graham MC, Phipps WR, Partridge AB, Paulhamus LA: Lack of effect of shortened sperm-oocyte exposure time on in vitro fertilization (IVF) and embryo quality. Fertil Steril 1999;72 (Suppl 1):S15 Hammitt DG, Barud KM, Galanits TM, Wentworth MA, Walker DL, Damario MA, Singh AP, Dumesic DA: Comparison of short and long sperm-oocyte coincubation in organ culture dishes (OCD) and tubes (TU). Fertil Steril 1999;72 (Suppl 1):S15-S16 Ferriani RA, Moraes LAM, Araujo MCPM, Sala MM: Reducing the time of sperm-oocyte interaction in human IVF. Fertil Steril 1998;70 (Suppl 1):S95 Swenson K, Summers-Chase D, Check JH, Choe J: Preliminary evidence that shortening the incubation time of sperm and oocyte may improve implantation rates with in vitro fertilization (IVF). Fertil Steril 1998;69:594-595 Gianaroli L, Magli MC, Ferraretti AP, Fiorentino A, Tosti E, Panzella S, Dale B: Reducing the time of sperm-oocyte interaction in human in-vitro fertilization improves the implantation rate. Hum Reprod 1996;11:166-171 Gianaroli L, Fiorentino A, Magli MC, Ferraretti AP, Montanaro N: Prolonged sperm-oocyte exposure and high sperm concentration affect human embryo viability and pregnancy rate. Hum Reprod 1996;11:2507-2511 Free DA, Merryman DC, Stringfellow SE, Long CA, Houserman VL, Honea KL, Meintjes M: Limited oocytesperm co-incubation time does not improve embryo quality, implantation or pregnancy rates in patients undergoing in vitro fertilization. Fertil Steril 1998;70 (Suppl 1):S98-S99 Swenson K, Check JH, Summers-Chase D, Choe JK, Nazari A: Arandomized study comparing the effect of standard versus short incubation of sperm and oocyte on subsequent pregnancy and implantation rates following in vitro fertilization-embryo transfer (IVF-ET). Fertil Steril 1999;72 (Suppl 1):16S-17S Johnson JE, Boone WR, Blackhurst DW: Manual versus computer-automated semen analyses. Part I. Comparison of counting chambers. Fertil Steril 1996;65:150-155 Boone WR, Johnson JE, Price TM, Bowers BK, Morris MD, Crane MM, Bates GW: In vitro fertilization and embryo transfer (IVF-ET) comes to the upstate. J SC Med Assoc 1994;90:360-366 May JV, Hanshew K: Organization of the in vitro fertilization/embryo transfer laboratory. In Handbook of the Laboratory Diagnosis and Treatment of Infertility, BA Keel, BW Webster (eds). Boca Raton, FL, CRC Press, 1990, pp 291-329 Kochhar HPS, King WA: Timing of sperm oocyte interaction and its effect on cleavage and development rate in a bovine IVF system. Theriogenology 1998;49:288 Rehman N, Collins AR, Suh TK, Wright RW Jr: Effect of sperm exposure time on in vitro fertilization and embryo development of bovine oocytes matured in vitro. Theriogenology 1994;41:1447-1452 Author information Authors and Affiliations Rights and permissions About this article Cite this article Boone, W.R., Johnson, J.E. Clinical Assisted Reproduction: Extending the Coincubation Time of Gametes Improves In Vitro Fertilization. J Assist Reprod Genet 18, 18–20 (2001). https://doi.org/10.1023/A:1026442411577 Issue date: DOI: https://doi.org/10.1023/A:1026442411577

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (1)

Cited by (1)

Source provenance

europepmc
last seen: 2026-08-11T06:11:44.160905+00:00