[Morphological and clinical aspects of malignant vascular tumors of the uterus (author's transl)]

Summary Two vascular tumors of the uterus, hemangioendothelioma and hemangiopericytoma, were readily distinguishable from each other on the basis of their light microscopic characteristics. By comparing these tumors with other uterine neoplasmas with a prominent vascular component and by reviewing the present literature the following conclusions have been drawn: - 1. In their light microscopic appearance the vascular tumors of the uterus completely resemble those found in other organs. There are a number of morphological criteria which usually allow differentiation of these tumors from proliferative endolymphatic stromatosis and from vascular leiomyomas. - 2. The treatment of choice is total hysterectomy and bilateral salpingo-oophorectomy. It seems likely that hemangiopericytomas are relatively radio-resistant. The hemangioendothelioma and the proliferative endolymphatic stromatosis on the contrary usually respond very well to radiotherapy. - 3. The recurrence rate of these three tumors ist varying considerably. Hemangioendotheliomas are characterized by early recurrence in over 50%, while endolymphatic stromatosis has a recurrence rate of about 20%. Likewise hemangiopericytomas seldom recur or metastasise. Zusammenfassung In der vorliegenden Arbeit werden anhand eines Hämangiopericytoms und eines Hämangioendothelioms des Uterus die Strukturmerkmale beider Tumorformen sowie die differentialdiagnostischen Kriterien zur Abgrenzung von anderen gefäßreichen Tumoren des Uterus (endolymphatische Stromatose, gefäßreiches Leiomyom) beschrieben. Für die Behandlung dieser Geschwülste gilt als Methode der Wahl die totale Uterusexstirpation unter Mitnahme beider Adnexe. Im Gegensatz zu den relativ strahlenresistenten Hämangiopericytomen scheinen die Hämangioendotheliome und die endolymphatischen Stromatosen gut auf Strahlentherapie anzusprechen. Die Prognose ist für die Hämangiopericytome als relativ günstig anzusehen. Bei den Hämangioendotheliomen kommt es meist frühzeitig zu Rezidiven. Similar content being viewed by others Literatur Backwinkel, K. D., Diddams, J. A.: Hemangiopericytome. Cancer,25, 896–901 (1970) Böcker, W., Stegner, H.-H.: Zur Klinik und Pathologie der Uterussarkome. Arch. Gynäkol. Arch. Gynäk.,216, 235–255 (1974) Charles, A. H.: Hemangiopericytoma uteri. J. Obstet. Gyn.68, 648–651 (1961) Cohen, J. S., Ingleby, H., Gayl, J.: Hemangioendothelioma of the uterus. Am. J. Obstet. Gynec.57, 592–595 (1949) Embrey, M. P., Yates, M. J.: Hemangiopericytoma of the uterus as a cause of haemoperitoneum. J. Obstet. Gyn.73, 683–685 (1966) Greene, R. R., Gerbie, A. B., Gerbie, M. V., Eckman, T. R.: Hemangiopericytoma of the uterus. Am. J. Obstet. Gyn.106, 1020–1031 (1970) Hunter, W. C., Nohlgren, J. E., Lancefield, S. M.: Stromal endometriosis or endometrial sarcoma. Am. J. Obstet. Gynec.72, 1072 (1956) Kempson, R. L.: Sarcomas and related neoplasms. In: The uterus. Editors: Norris, H. J., Hertig, A. T., Abell, M. R., William and Wilkins Company 1973 Kuhn, C., Rosai, J.: Tumors arising from pericytes. Arch. Path.88, 653–663 (1969) Laffargue, P., Cabanne, F., Nosny, Y.: Sarcomes du corps uterin. Gyn. Obst. (Paris)65, 423–454 (1966) Mainwaring, A. R.: Hemangiopericytoma of the uterus. J. Obstet. Gyn.68, 652–655 (1961) O'Brien, P., Brasfield, R. D.: Hemangiopericytoma. Cancer18, 249–252 (1965) Pedowitz, P., Felmus, S. B., Grayzel, D. M.: Vascular tumors of the uterus. II. Malignant vascular tumors. Am. J. Obstet. Gyn.69, 1309–1322 (1955) Probst, A.: Die Angioblastomatose des Uterus. Virchows Arch. Path. Anat.337, 555–572 (1964) Purola, E., Strandell, R.: Hemangioendothelioma of the uterus. Ann. Chir. Gynaecol. Fenn.56, 102–104 (1967) Silverberg, S. G., Wilsson, M. A., Board, J. A.: Hemangiopericytoma of the uterus: An ultrastructural study. Am. J. Obstet. Gyn.110, 397–404 (1972) Stout, A. P., Lattes, R.: Tumors of the soft tissues. Atlas of tumor pathology, fasc. I. Armed Forces Institute of Pathology 1966 Stout, A. P., Murray, M. R.: Hemangiopericytoma. A vascular tumor featuring Zimmermanns pericytes. Ann. Surg.116, 26–33 (1942) Weiser, G., Probst, A.: Zur Histogenese der Angiomatosis uteri — sog. Stromatosis uteri. Virch. Arch. Path. Anat.361, 229–239 (1973) Author information Authors and Affiliations Rights and permissions About this article Cite this article Böcker, W., Hinz, W. Zur Problematik der malignen Gefäßgeschwülste des Uterus. Arch. Gynak. 217, 293–302 (1974). https://doi.org/10.1007/BF00669736 Received: Issue date: DOI: https://doi.org/10.1007/BF00669736