A review on the stem cell therapy and an introduction to exosomes as a new tool in reproductive medicine

Uldouz Kharazi, Badalzadeh R, Reza Badalzadeh
Reproductive biology · 2020 · vol. 20(4) , pp. 447–459 · doi:10.1016/j.repbio.2020.07.002 · PMID:32900639 · W3083036771
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This review discusses stem cell therapy and introduces exosomes as a novel tool for applications in reproductive medicine.

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Abstract

Stem cell therapy and exosome therapy are the two experimental methods that are now at the center of attention. Various types of stem cells, especially mesenchymal stem cells and spermatogonial stem cells have been widely administrated in reproductive medicine. However, due to the limitation of injecting living cells, using their paracrine secretions such as exosomes seems to be a better option. Exosomes show regenerative, pro-angiogenic, anti-apoptotic, anti-inflammatory, anti-hypoxic, and anti-fibrotic characteristics. They can induce cell proliferation, cell viability, migration, oogenesis, spermatogenesis, capacitation, acrosome reaction, and embryonic implantation. Exosomes have shown promising results in regenerative medicine such as liver fibrosis, stroke, cardiac ischemia, and skin injuries. Exosomes have been used to treat reproductive diseases such as erectile dysfunction and primary ovarian insufficiency. However, the study of exosomes in reproductive medicine is limited. In this article, we are going to review some of the researches on the use of stem cells and exosomes in reproductive medicine and suggest administration of a combination of exosomes for alleviating the symptoms of endometriosis and asthenozoospermia based on previous studies.

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MeSH descriptors

Cell- and Tissue-Based Therapy Exosomes Reproductive Medicine Stem Cell Transplantation Adult Germline Stem Cells Adult Germline Stem Cells Animals Embryonic Development Erectile Dysfunction Erectile Dysfunction Exosomes Female Humans Infertility Infertility Male Mesenchymal Stem Cell Transplantation Oogenesis Primary Ovarian Insufficiency Primary Ovarian Insufficiency

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