Myometrium: Non—Neoplastic Conditions and Miscellaneous Neoplasms

In: Atlas of Gynaecological Pathology · 1983 · pp. 83–86 · doi:10.1007/978-94-015-7312-2_17 · W152529294
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Adenomyosis is defined by endometrial tissue located deep within the myometrium, accompanied by hypertrophy of surrounding smooth muscle fibers.

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This chapter describes the myometrium in parous women and focuses on non-neoplastic conditions, especially adenomyosis, defined by the presence of endometrial tissue deep within the myometrium along with surrounding smooth muscle hypertrophy. It discusses how the normal endometrium–myometrium interface is often irregular and can create apparently isolated intramyometrial endometrial islands depending on how tissue is sectioned, making “deep” a key definitional point. The authors note disputes over diagnostic criteria, arguing that earlier proposed microscopic-field thresholds are poorly defined and instead preferring a more specific measure: intramyometrial glands located more than one quarter of the full uterine wall thickness below the endometrial–myometrial junction. This paper is centrally about endometriosis and/or adenomyosis — it specifically defines and reviews adenomyosis, including the histologic basis for “deep” intramyometrial endometrial tissue.

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Abstract

This is a disease principally of parous women in the later years of their reproductive life, and is characterized by the presence of endometrial tissue deep within the myometrium (Figure 17.1): there is almost invariably an associated hypertrophy of smooth muscle fibres around the islands of ectopic endometrium. When considering this condition it has always to be borne in mind that the interface between the normal endometrium and the myometrium is often very irregular, and that tangential cutting of the basal endometrium may produce apparently isolated islands of endometrial tissue surrounded by myometrium. It is for this reason that the word 'deep' is insisted upon in the definition of adenomyosis though there has been considerable dispute as to its interpretation. Very often it has been suggested that to justify a diagnosis of adenomyosis the ectopic endometrium should be one high power microscopic field, or a proportion of a low power microscopic field, below the base of the endometrium; but these are poorly defined criteria which take no account of variations in myometrial thickness, and the defining criterion that the intramyometrial glands must be at a distance of more than one quarter of the full thickness of the uterine wall below the endometrial—myometrial junction is to be preferred. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

Hendrickson, M. R. and Kempson, R. L. (1980). Surgical Pathology of the Uterine Corpus, (Philadelphia, London, Toronto: W. B. Saunders ) Langlois, P. L. (1970). The size of the normal uterus. J. Reprod. Med., 4, 220–228 Tiltman, A. J. (1980). Adenomatoid tumours of the uterus. Histopathology, 4, 437–443 Quigley, J. C. and Hart, W. R. (1981). Adenomatoid tumors of the uterus. Am. J. Clin. Pathol., 76, 627–635 Ferenczy, A., Fenoglio, J. and Richart, R. M. (1972). Observations on benign mesothelioma of the genital tract (adenomatoid tumor): a comparative ultrastructural study. Cancer, 30, 244 - 260 Salazar, H., Kanbour, A. and Burgess, F. (1972). Ultrastructure and observations on the histiogenesis of mesotheliomata ‘adenomatoid tumors’ of the female genital tract. Cancer, 29, 141 - 152 Langley, F. A. (1973). The pathology of the myometrium. In Fox, H. and Langley, F. A. (eds.). Postgraduate Obstetrical and Gynaecological Pathology. pp. 147 - 175. ( Oxford: Pergamon Press ) Silverberg, S. G., Willson, M. A. and Board, J. A. (1971). Hemangiopericytoma of the uterus: an ultrastructural study. Am. J. Obstet. Gynecol., 110, 397–-404 Langley, F. A. (1976). Malignant tumours of the uterine mesenchyme. Clin. Obstet. Gynaecol., 3, 425 - 457 Author information Authors and Affiliations Rights and permissions Copyright information © 1983 H. Fox and C. H. Buckley About this chapter Cite this chapter Fox, H., Buckley, C.H. (1983). Myometrium: Non—Neoplastic Conditions and Miscellaneous Neoplasms. In: Atlas of Gynaecological Pathology. Current Histopathology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-7312-2_17 Download citation DOI: https://doi.org/10.1007/978-94-015-7312-2_17 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-015-7314-6 Online ISBN: 978-94-015-7312-2 eBook Packages: Springer Book Archive

Keywords

- Malignant Mesothelioma - Endometrial Tissue - Endometrial Stromal Sarcoma - Normal Endometrium - Smooth Muscle Fibre These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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