Myometrium: Non—Neoplastic Conditions and Miscellaneous Neoplasms
Adenomyosis is defined by endometrial tissue located deep within the myometrium, accompanied by hypertrophy of surrounding smooth muscle fibers.
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This chapter describes the myometrium in parous women and focuses on non-neoplastic conditions, especially adenomyosis, defined by the presence of endometrial tissue deep within the myometrium along with surrounding smooth muscle hypertrophy. It discusses how the normal endometrium–myometrium interface is often irregular and can create apparently isolated intramyometrial endometrial islands depending on how tissue is sectioned, making “deep” a key definitional point. The authors note disputes over diagnostic criteria, arguing that earlier proposed microscopic-field thresholds are poorly defined and instead preferring a more specific measure: intramyometrial glands located more than one quarter of the full uterine wall thickness below the endometrial–myometrial junction. This paper is centrally about endometriosis and/or adenomyosis — it specifically defines and reviews adenomyosis, including the histologic basis for “deep” intramyometrial endometrial tissue.
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- W58359445 via openalex
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