Preliminary report on the use of tamoxifen in the treatment of endometriosis

Tamoxifen, an antiestrogen, was used in the treatment of two women with a long-standing history of endometriosis. After a 6-month period of treatment, both patients were symptom free and both showed a marked decrease in the size of their endometriotic lesions. It was significant that ovulation was documented in both patients while receiving the treatment regimen. The use of tamoxifen as an alternative modality in the treatment of endometriosis, especially for women desiring to conceive, is discussed.