Introduction
This Atlas presents typical and unusual pathological features of clear cell carcinoma of the ovary based on a central pathological review of 652 cases from an international clinical trial.
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This atlas introduction describes clear cell carcinoma (CCC) of the ovary as a distinct clinical and pathological ovarian cancer subtype, noting that earlier reports were often limited to small case numbers. It explains that the Japan Gynecologic Oncology Group conducted an international clinical trial that collected 652 CCC cases and performed central pathological review, and that the atlas documents both typical and unusual pathological features identified through that review. A key limitation is that the work is organized around the trial’s central review dataset and focuses on pathology description rather than broader biologic mechanisms or outcomes. Relevance to endometriosis: endometriosis is cited in the referenced literature within this chapter’s background (e.g., as a known link to ovarian cancer subtype risk and as context for clear cell ovarian cancer arising from endometriosis), though the chapter’s main focus is introducing the atlas based on central pathological review.
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