Serum levels of androgens and prostate-specific antigen in endometriosis

M S Evsen, Mehmet Sıddık Evsen, Evsen MS, M E Sak, Muhammed Erdal Sak, Sak ME, H E Soydinc, Hatice Ender Soydinç, Soydinc HE, S Guven, Süleyman Güven, Basaranoglu S, S Basaranoglu, Sevgen Tanır Başaranoğlu, Namık Kemal Hatipoğlu, Hatipoglu NK, N K Hatipoglu, Osman Evliyaoğlu, O Evliyaoglu, Evliyaoglu O, Gul T, Talip Gül, T Gul
Clinical and experimental obstetrics & gynecology · 2014 · vol. 41(4) , pp. 432–435 · doi:10.12891/ceog16712014 · PMID:25134292 · W2401468627
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Serum levels of testosterone, androstenedione, DHEA, and DHEA-S were higher, though not significantly, in advanced endometriosis patients compared to controls, with no significant difference in PSA levels.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This prospective case-control study compared advanced (Stage III/IV) endometriosis patients with controls by measuring basal serum levels of total and free testosterone, androstenedione, DHEA, DHEA-S, and prostate-specific antigen (PSA) in the early follicular phase of the menstrual cycle. The authors found that mean levels of multiple androgens (T, fT, A, DHEA, DHEA-S) were higher in the endometriosis group, but these differences were not statistically significant, and PSA levels were also similar between groups (0.0074 ± 0.0120 ng/ml vs 0.0059 ± 0.0056 ng/ml; p = 0.58). The main caveat explicitly reflected in the findings is the lack of statistical significance for all reported group differences, limiting evidence for a meaningful separation between groups. This paper is centrally about endometriosis — it evaluates serum androgen fractions and PSA levels in patients with Stage III/IV endometriosis compared with controls.

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Abstract

OBJECTIVE: The aim of the present study was to evaluate the levels of serum androgens and prostate-specific antigen (PSA) levels in patients with endometriosis. MATERIALS AND METHODS: Patients with Stage III/IV (advanced stage) endometriosis were compared to controls with respect to basal serum levels of total testosterone (T), free testosterone (fT), androstenedion (A), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulphate (DHEA-S), and PSA in the early follicular phase of menstrual cycle for this prospective case control study. RESULTS: Level of T, fT, A, DHEA, and DHEA-S were higher in patients with endometriosis when compared to control subjects, but the difference was not statistically significant. The mean PSA level was 0.0074 +/- 0.0120 ng/ml in patients with endometriosis and 0.0059 +/- 0.0056 ng/ml in control group and there was no statistically significant difference between groups (p = 0.58). CONCLUSION: Serum basal androgens and PSA levels are higher in endometriosis group with respect to control but the differences are not statistically significant.
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Abstract

Objective: The aim of the present study was to evaluate the levels of serum androgens and prostate-specific antigen (PSA) levels in patients with endometriosis. Materials and Methods: Patients with Stage III/IV(advanced stage) endometriosis were compared to controls with respect to basal serum levels of total testosterone (T), free testosterone (fT), androstenedion (A), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulphate (DHEA-S), and PSA in the early follicular phase of menstrual cycle for this prospective case control study. Results: Level of T, fT, A, DHEA, and DHEA-S were higher in patients with endometriosis when compared to control subjects, but the difference was not statistically significant. The mean PSA level was 0.0074 ± 0.0120 ng/ml in patients with endometriosis and 0.0059 ± 0.0056 ng/ml in control group and there was no statistically significant difference between groups (p = 0.58). Conclusion: Serum basal androgens and PSA levels are higher in endometriosis group with respect to control but the differences are not statistically significant.

Keywords

- Endometriosis - Androgens - Prostate-specific antigen

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Condition tags

endometriosis

MeSH descriptors

Androstenedione Dehydroepiandrosterone Endometriosis Prostate-Specific Antigen Testosterone Adult Androstenedione Case-Control Studies Dehydroepiandrosterone Endometriosis Endometriosis Female Follicular Phase Follicular Phase Humans Prospective Studies Prostate-Specific Antigen Testosterone Young Adult

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