Effect of Different Doses and Courses of Mifepristone in the Treatment of Rats' Endometriosis

Yuling Hu, Qiao Lin, Lin Yang, Zhong Lan-pin
In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2012 · vol. 8(6) , pp. 696–699 · doi:10.3877/cma.j.issn.1673-5250.2012.06.005 · W3032629990
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

Mifepristone significantly reduced endometriosis ectopic lesions in rats, with no difference in efficacy between high and low doses or varying treatment durations.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The study investigated how different doses and treatment durations of mifepristone affect lesion growth in a rat model of endometriosis, using 79 successfully modeled rats randomized to high-dose (2.604 mg/kg·day), low-dose (1.041 mg/kg·day), and peanut oil control, with 7 deaths during treatment. Lesions were additionally subdivided by course length (20, 30, or 40 days), and the primary outcome was the reduction rate in ectopic lesion volume. Both the high- and low-dose groups showed significantly reduced lesion volumes compared with controls and compared with baseline (P<0.05), but there was no significant difference between the two doses and no statistically significant differences across the different treatment durations (reported P=0.662, 0.559, 0.145, 0.057). The authors conclude that mifepristone inhibits ectopic lesion growth without dose- or duration-dependent enhancement within the tested ranges. This paper is centrally about endometriosis—rat endometriosis models testing different mifepristone doses and courses.

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Abstract

Objective To investigate the effect of different dosages and different treatment methods of mifepristone in rat's endometriosis(EMs). Methods A total of 79 rats were selected to establishment of models of EMs, and were randomly divided into high-dose group[dosages of 2.604 mg/(kg·d)], low-dose group[dosages of 1.041 mg/(kg·d)], control group(placebo of 1 mL peanut oil)to determine the drugs effects of the ectopic lesions reduce by medication. There were 7 rats died during treatment period. According to different courses of treatment 20 days, 30 days and 40 days, 72 rats were divided into 9 sub-groups to determine the effectiveness of treatment. Results After treatment of mifepristone, ectopic lesions of EMs were significantly reduced than those before treatment in low-dose group and high-dose group (P<0.05); in low-dose group and high-dose group there were significance difference than those in control group (P<0.05); however, curative effects of mifepristone between low-dose group and high-dose group (P=0.662) or different courses of treatment 20 days, 30 days and 40 days subgroups had no statistically significant difference (P=0.559, 0.145, 0.057). Conclusions Mifepristone could inhibit the growth of EMs ectopic lesions. There was no statistically significant difference to treatment models of EMs rats by medication dosages of 2.604 mg/(kg·d), 1.041 mg/(kg·d) or different courses of treatment by medication 20 days, 30 days and 40 days subgroups. Key words: endometriosis; mifepristone; rat
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Objective

To investigate the effect of different dosages and different treatment methods of mifepristone in rat's endometriosis(EMs).

Methods

A total of 79 rats were selected to establishment of models of EMs, and were randomly divided into high-dose group[dosages of 2.604 mg/(kg·d)], low-dose group[dosages of 1.041 mg/(kg·d)], control group(placebo of 1 mL peanut oil)to determine the drugs effects of the ectopic lesions reduce by medication. There were 7 rats died during treatment period. According to different courses of treatment 20 days, 30 days and 40 days, 72 rats were divided into 9 sub-groups to determine the effectiveness of treatment.

Results

After treatment of mifepristone, ectopic lesions of EMs were significantly reduced than those before treatment in low-dose group and high-dose group (P<0.05); in low-dose group and high-dose group there were significance difference than those in control group (P<0.05); however, curative effects of mifepristone between low-dose group and high-dose group (P=0.662) or different courses of treatment 20 days, 30 days and 40 days subgroups had no statistically significant difference (P=0.559, 0.145, 0.057).

Conclusions

Mifepristone could inhibit the growth of EMs ectopic lesions. There was no statistically significant difference to treatment models of EMs rats by medication dosages of 2.604 mg/(kg·d), 1.041 mg/(kg·d) or different courses of treatment by medication 20 days, 30 days and 40 days subgroups. | [1] | Kettel LM, Murphy AA, Morales AJ, et al. Preliminary report on the treatment of endometriosis with low dose mifepristone (RU 486)[J]. Am J Obstet Gynecol, 1998, 178:1151-1156. | | [2] | Kettel LM, Murphy AA, Morales AJ, et al. Treatment of endometriosis with the antiprog-esterone mifepristone (RU486)[J]. Fertil Steril, 1996, 65:23-28. | | [3] | Kettel LM, Murphy AA, Mortola JF, et al. Endocrine responses to long-term administration of the antiprogesterone RU486 in patient with pelvic endometriosis[J]. Fertil Steril, 1991, 56:402-407. | | [4] | Shang HL, Li GY, Liu HH, et al. Laparoscopic surgery combined mifepristone treatment for ovarian endometrial cyst of 55 Cases[J/CD]. Chin J Gynecol Obstet Pediatr:Electron Ed, 2005, 1(2):175-176. | | [5] | Pelch KE, Sharpe-Timms KL, Nagel SC.Mouse model of surgically-induced endometriosis by auto-transplantation of uterine tissue[J]. Visual Exp, 2012, 59:3388-3396. | | [6] | Grümmer R. Animal models in endometriosis research[J].Human Reprod Update, 2006, 12(5):641-649. | | [7] | Matsuzaki S, Canis M, Darcha C, et al. Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats[J]. Fertil Steril, 2004, 82(6):1609-1615. | | [8] | Rene V, Francisco Q, Rosa B, et al. Intraperitoneal recombinant interleukin-2 activates leuko cytes in rat endometriosis[J]. J Reprod Immunol, 2007, 74:124-132. | | [9] | Rosa-e-Silva JC, Garcia SB, Rosa-e-Silva AC., et al. Increased cell proliferation in experimentally induced endometriosis in rabbits[J]. Fertil Steril, 2010, 93(5):1637-1642. | | [10] | Carbonelli Esteve JL, Boza OP, Riverón Cobo AM, et al. Treatment with 5 mg or 25 mg of mifepristone daily for six months. A randomized double-blind study[J]. Progr Obstet Gynecol, 2012, 55:51-59. | | [11] | Yang MY, Rajamahendran R. Involvementofapoptosis in the atresia of nonovulatory follicle during the bovine estrous cycle[J].Biol Reprod, 2000, 63(5):1313-1321. | | [12] | rentice A, Deary A, Goldbeck-Wood S, et al. Gonadotrophin-releasing hormone analogues for pain associated with endometriosis[J].(Cochrane Review)In: The Cochrane Library, 2007, Issue 2. | | [13] | Irving M, Spitz SM, Chabbert-Buffet N, et al.Management of patients receiving long-term treatment with mife- pristine[J]. Fertil Steril, 2005(6):1720-1726. | | [1] | 刘思锐, 赵辰阳, 张睿, 张一休, 杨萌. 多普勒超声对孕鼠子宫动脉不同节段血流动力学参数的评估[J/OL]. 中华医学超声杂志（电子版）, 2024, 21(09): 877-883. | | [2] | 朱成美, 赵巧梅, 邓学东. 经阴道超声联合生理盐水灌注直肠子宫陷凹对腹膜型子宫内膜异位症的诊断价值[J/OL]. 中华医学超声杂志（电子版）, 2024, 21(01): 32-36. | | [3] | 李朋, 苗立帅, 朱智奇. 四氢嘧啶对大鼠关节软骨细胞的保护作用[J/OL]. 中华关节外科杂志(电子版), 2024, 18(01): 69-77. | | [4] | 林琳, 田思萌, 于永华, 徐飞飞, 黄明莉. 干细胞及其外泌体治疗宫腔黏连的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(03): 271-275. | | [5] | 邵小丽, 林燕, 张玲玲, 韩亚琴. 超声引导下子宫肌瘤注射聚桂醇硬化术联合术后米非司酮治疗临床疗效分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(03): 353-360. | | [6] | 乔林. 子宫内膜异位症鉴别诊断病例分享[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(02): 248-. | | [7] | 杨文飞, 郝嘉文, 鲁梦远, 赵学刚, 李聪颖, 盖晨阳, 张晶, 张庆富. 高压电烧伤对大鼠心肌氧化应激的影响及N-乙酰半胱氨酸的干预作用[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(02): 106-112. | | [8] | 张礼刚, 邹志辉, 许顺, 蔡可可, 胡永涛, 梁朝朝. 酒精对慢性非细菌性前列腺炎中T淋巴细胞变化的影响研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(01): 74-81. | | [9] | 赛甫丁·艾比布拉, 买买提·依斯热依力, 李义亮, 王永康, 王志, 克力木·阿不都热依木. 不同材质补片修补对腹壁疝大鼠腹横筋膜组织转化生长因子-β1及Collagen合成代谢的作用[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(02): 161-167. | | [10] | 刘锦程, 王斌, 张雯, 张明周, 刘禹, 叶东樊, 黄赞胜, 邱凌霄, 卿斌, 王创业, 王南博, 王苹, 郭宇航, 周培花, 程秋霞, 徐智. 肺泡灌洗液RASSF1A及SHOX2甲基化联合径向超声特征对肺结节性质鉴别诊断的意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 505-511. | | [11] | 张蕾, 彭超, 周应芳. 直肠阴道隔子宫内膜异位症腹腔镜手术技巧[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 257-261. | | [12] | 胡启明, 鄢潇, 尤志学, 黄骁昊. 经瘢痕处单孔腹腔镜下切除多病灶腹壁子宫内膜异位症[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 314-317. | | [13] | 芦煜, 李振宇, 吴承东, 周仲伍. 肛周子宫内膜异位症一例报告[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 431-434. | | [14] | 陈娟, 邓静敏. 胸部子宫内膜异位综合征的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(01): 96-100. | | [15] | 洪凡, 陈敦金, 傅洋, 梁新月, 吴毅, 王晓怡. 体外受精-胚胎移植妊娠合并前置胎盘临床研究[J/OL]. 中华产科急救电子杂志, 2024, 13(03): 176-182. | | 阅读次数 | ||||| | 全文 | | |||| | 摘要 | | |||| 版权所有 中华医学会 中华医学电子音像出版社有限责任公司 京ICP备14006079号-1 网络出版服务许可证：(署)网出证(京)字第075号 AI 小 编 AI小编

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