{"paper_id":"69a68920-44ab-44b2-b02c-11bd8d939325","body_text":"中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (06) : 696 -699. doi: 10.3877/cma.j.issn.1673-5250.2012.06.005\n所属专题： 文献；\n论著\n不同剂量及疗程米非司酮治疗大鼠子宫内膜异位症的疗效\n- 1. 610041 成都，四川大学华西第二医院妇产科\n- 1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China\n目的\n探讨不同剂量、不同疗程的米非司酮(mifepristone)对减小子宫内膜异位症(EMs)病灶的疗效。\n方法\n建立EMs大鼠模型，将建模成功的79只大鼠随机分为高剂量组[米非司酮剂量为2.604 mg/(kg·d)]、低剂量组[米非司酮剂量为1.041 mg/(kg·d)]及对照组(1 mL花生油)，治疗期内死亡7只；将3组再按不同疗程分为20 d亚组，30 d亚组，40 d亚组，观察用药20 d，30 d及40 d时异位病灶体积的减小率，从而判断治疗的有效性。\n结果\n高剂量组及低剂量组分别与对照组疗效比较，异位病灶体积均显著减小，差异均有统计学意义(P<0.05)；而低剂量组与高剂量组的异位病灶体积减小率比较，差异无统计学意义(P＝0.662)，用药20 d，30 d及40 d时病灶减小率比较，差异亦无统计学意义(P＝0.559，0.145，0.057)。\n结论\n米非司酮可抑制EMs异位病灶的生长，低剂量组与高剂量组抑制趋势无显著差异，而且延长治疗周期，亦不能增强该药对异位内膜生长的抑制作用。\nObjective\nTo investigate the effect of different dosages and different treatment methods of mifepristone in rat's endometriosis(EMs).\nMethods\nA total of 79 rats were selected to establishment of models of EMs, and were randomly divided into high-dose group[dosages of 2.604 mg/(kg·d)], low-dose group[dosages of 1.041 mg/(kg·d)], control group(placebo of 1 mL peanut oil)to determine the drugs effects of the ectopic lesions reduce by medication. There were 7 rats died during treatment period. According to different courses of treatment 20 days, 30 days and 40 days, 72 rats were divided into 9 sub-groups to determine the effectiveness of treatment.\nResults\nAfter treatment of mifepristone, ectopic lesions of EMs were significantly reduced than those before treatment in low-dose group and high-dose group (P<0.05); in low-dose group and high-dose group there were significance difference than those in control group (P<0.05); however, curative effects of mifepristone between low-dose group and high-dose group (P=0.662) or different courses of treatment 20 days, 30 days and 40 days subgroups had no statistically significant difference (P=0.559, 0.145, 0.057).\nConclusions\nMifepristone could inhibit the growth of EMs ectopic lesions. There was no statistically significant difference to treatment models of EMs rats by medication dosages of 2.604 mg/(kg·d), 1.041 mg/(kg·d) or different courses of treatment by medication 20 days, 30 days and 40 days subgroups.\n| [1] |\nKettel LM, Murphy AA, Morales AJ, et al. Preliminary report on the treatment of endometriosis with low dose mifepristone (RU 486)[J]. Am J Obstet Gynecol, 1998, 178:1151-1156.\n|\n| [2] |\nKettel LM, Murphy AA, Morales AJ, et al. Treatment of endometriosis with the antiprog-esterone mifepristone (RU486)[J]. Fertil Steril, 1996, 65:23-28.\n|\n| [3] |\nKettel LM, Murphy AA, Mortola JF, et al. Endocrine responses to long-term administration of the antiprogesterone RU486 in patient with pelvic endometriosis[J]. Fertil Steril, 1991, 56:402-407.\n|\n| [4] |\nShang HL, Li GY, Liu HH, et al. Laparoscopic surgery combined mifepristone treatment for ovarian endometrial cyst of 55 Cases[J/CD]. 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