Does endometriosis have an effect on the survival of women with synchronous endometrial and ovarian cancer?

Çağatay Engin, Hale Göksever Çelik, Hamdullah Sözen, Semen Önder, Merve Baktiroğlu, Merve Baktıroğlu, Samet Topuz, Mehmet Yavuz Salihoğlu
In: Journal of Endometriosis and Pelvic Pain Disorders · 2019 · vol. 11(4) , pp. 185–193 · doi:10.1177/2284026519893537 · W2994977348
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that the presence of endometriosis did not significantly affect the progression-free or overall survival of women diagnosed with synchronous endometrial and ovarian cancer.

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Abstract

Purpose: Synchronous endometrial and ovarian cancer is defined as the concurrent presence of ovarian cancer with endometrial cancer. We aimed to evaluate whether there is an effect of endometriosis on progression-free survival and overall survival of women with synchronous endometrial and ovarian cancer. We also compared these findings with the patients having endometrial-only tumors and ovarian-only tumors. Methods: The patients who underwent surgery for endometrioid or clear-cell endometrial-only tumors and/or ovarian-only tumors and synchronous endometrial and ovarian cancer between 2005 and 2016 were included in this cohort study. The effect of the presence of endometriosis on progression-free survival and overall survival in these women who met the criteria was determined using statistical methods. Women were also compared regarding their demographic, clinical, and pathological characteristics. Results: A total of 176 patients were included in this study. All histology types of tumors located in endometrium or ovary were endometrioid or clear-cell cancer. Endometriosis was present in 62 patients (35.2%), whereas adenomyosis was present in 44 patients (25%). Endometriosis was diagnosed more frequently in women with ovarian-only tumors and synchronous endometrial and ovarian cancer than those with endometrial-only tumors (59.2% vs 5.7%, p < 0.001 and 45.7% vs 5.7%, p < 0.001, respectively). The patients with endometriosis showed no significantly longer progression-free survival and overall survival (hazard ratio = 1.70; 95% confidence interval = 0.48–6.03; p = 0.408 and hazard ratio = 1.67; 95% confidence interval = 0.30–9.44; p = 0.562, respectively). The presence of endometriosis was a stronger predictor for progression-free survival and overall survival comparing with the presence of adenomyosis. Conclusion: The women with synchronous endometrial and ovarian cancer should be informed that endometriosis has no detrimental effect on progression-free survival and overall survival.

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endometriosisadenomyosis

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