CHIARI FROMMEL SYNDROME - AN EXHAUSTIVE REVIEW Review Article

Juhi Rao, Neha Sharma, Ekta Singh, Rajani Chauhan, Swapnil Sharma
2012 · W2183451072
article OA: closed CC0 Metadata only
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Abstract

A rare endocrine disorder, an orphan disease, described by a German surgeon, Chiari Johann Baptist, and Frommel Richard Julius Ernst, a German gynecologist is Chiari‐Frommel syndrome. It affects the women (usually young, 17‐35 years) who have recently given birth, suffer from galactorrhea, anovulation, and amenorrhea, continuing for an abnormal period of time, uterus atrophy, and is better known as Chiari‐Frommel syndrome in which hyperprolactinemia, eosinophillic hyperfunction is observed. But still its physiopathology remains unclear. The main targets of the disorder are those who are poorly nourished and complaint of lactation, lassitude, headaches, abdominal discomfort, mental distress, depression, breast enlargement, decreased size of uterus and cervix, weight gain, fatigue. Different findings reported are lot of variation but usually normal 17 ketosteroid excretion, atrophied endometrium, hypoestrogenic vaginal mucosa, normal glucose and insulin tolerance test, normal basal temperature curve. Related medications are cortef, eulexin, biperiden. Other drugs tried are tri‐p‐anisyl chloroethylene (TACE) with methyl testosterone, levodopa, bromoergocryptine, gamma amino butyric acid. Case reports have been also mentioned in the review.

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