Tamoxifen Alleviates Endometrial Fibrosis Induced by Anhydrous Ethanol in Rats

Hong Jiang, Jing Song, Mengjie Yang, Xinqin He, Hanjuan Wang, Xiaohui Deng
In: Discovery Medicine · 2024 · vol. 36(180) , pp. 160 · doi:10.24976/discov.med.202436180.15 · PMID:38273756 · W4391028080
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Tamoxifen administration reduced endometrial fibrosis and epithelial-mesenchymal transition indicators in rats with anhydrous ethanol-induced uterine damage.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This study tested whether tamoxifen can reduce endometrial fibrosis caused by anhydrous ethanol in rats. The authors induced endometrial fibrosis using anhydrous ethanol, then treated rats with tamoxifen and assessed fibrotic changes in the endometrium. They found that tamoxifen alleviated ethanol-induced endometrial fibrosis, indicating a protective antifibrotic effect in this animal model. This paper is centrally about endometriosis — it focuses on endometrial fibrosis and evaluates tamoxifen’s effects in a rat model that directly involves endometrial tissue pathology relevant to endometriosis.

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Abstract

BACKGROUND: As an estrogen receptor modulator, tamoxifen has been utilized in the treatment of fibrotic diseases. However, there is a limited body of research focusing on its potential application in addressing endometrial fibrosis conditions. Our research aims to investigate the effects of tamoxifen at different dosage levels in alleviating endometrial fibrosis and to elucidate its mechanisms of action during the initial stages of endometrial damage. METHODS: A total of thirty sexually mature, unmated female Sprague-Dawley (SD) rats were divided into six distinct groups. To establish the rat uterine adhesion model, the uterine cavity was subjected to perfusion with anhydrous ethanol. The control group received a saline solution, while the treatment group was administered oral estrogen in combination with tamoxifen at doses of 4 mg/kg/d, 20 mg/kg/d, and 40 mg/kg/d. Various techniques, including Hematoxylin and Eosin (HE) staining, Masson's Trichrome staining, Western Blotting analysis, and immunohistochemistry, were employed to assess changes in endometrial thickness, fibrosis, as well as alterations in indicators related to epithelial-mesenchymal transition (EMT), fibrosis, estrogen receptors within the endometrium, and vascular endothelial growth factor (VEGF). RESULTS: 0.0001). CONCLUSIONS: The results of this study suggest that the administration of a low dose (4 mg/kg/d) of tamoxifen in the early stages of endometrial injury may mitigate epithelial-mesenchymal transition (EMT) indicators and reduce fibrosis within the endometrium induced by anhydrous ethanol.
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